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Chelation Therapy in the Treatment of Metal Intoxication
This practical guide explores the use of chelation therapy—from its basic chemistry to available chelating antidotes and the application of chelating agents—in response to human exposure to a range of toxic metal compounds
Jan Aaseth (Author), Guido Crisponi (Author), Ole Anderson (Author)
9780128030721
Hardback, published 15 April 2016
388 pages
22.9 x 15.1 x 2.6 cm, 0.79 kg
"It surpasses its goal of showcasing the recent developments in the use of chelating agents for metal overexposure and metal storage diseases…This is a valuable addition to the field of metal toxicity and a handy resource for clinicians to gain an understanding of metal toxicity, diagnosis, and treatment. Score: 95 - 4 Stars" --Doody's
Chelation Therapy in the Treatment of Metal Intoxication presents a practical guide to the use of chelation therapy, from its basic chemistry, to available chelating antidotes, and the application of chelating agents. Several metals have long been known to be toxic to humans, and continue to pose great difficulty to treat. These challenges pose particular problems in industrial settings, with lead smelting known to be associated with hemopoietic alterations and paralyses, and the inhalation of mercury vapor in mercury mining being extremely detrimental to the central nervous system. Clinical experience has demonstrated that acute and chronic human intoxications with a range of metals can be treated efficiently by administration of chelating agents. Chelation Therapy in the Treatment of Metal Intoxication describes the chemical and biological principles of chelation in the treatment of these toxic metal compounds, including new chelators such as meso-2,3-dimercaptosuccinic acid (DMSA) and D,L-2,3-dimercapto-1-propanesulfonic acid (DMPS).
1. General chemistry of metals and chelating agents2. Chelating agents as therapeutic compounds3. Diagnosis and evaluation of metal poisonings4. Chelation Treatment during acute and chronic Metal Poisonings5. Decorpoation of Radionuclides6. Therapy of metal storage diseases (genetic diseases)7. Guidance and precautions for clinicians8. Concluding remarks
Subject Areas: Medical toxicology [MMGT]
