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Channels, Carriers, and Pumps
An Introduction to Membrane Transport
Links experimental data with theory for best understanding of membrane transport
Wilfred D. Stein (Author), Thomas Litman (Author)
9780124165793
Hardback, published 18 December 2014
422 pages
22.9 x 15.1 x 2.7 cm, 0.79 kg
"...an excellent resource on the current understanding of channels, carriers, and pumps as well as transport processes and their important roles in health and disease. Score: 91 = 4 Stars" --Doody's Praise for the previous edition:"It has become the "Bible" for my lab" --Tony Carruthers, Dean, Graduate School of Biomedical Sciences, UMass Medical School "The strength of this book is the way in which rigorous yet lucid expositions of the theoretical basis of various types of transport are integrated with illuminating discussions of experimental results. [This book] will continue to be rewarding reading when many symposium reports have become outdated, and it is warmly welcomed and recommended." --D.K. Apps, FEBS LETTERS, August 1991 "With so much diversity in biology it is exhilarating to read Stein’s attempt at synthesis. More of this is needed . . . Stein’s book should earn a place of its own, for it does something that few others attempt: it puts channels, carriers, and pumps under one roof . . . the book’s greatest value: its potential for catalytic action on sometimes disparate fields." --Louis J. DeFelice, California Institute of Technology, CELL, August 1991
An introduction to the principles of membrane transport: How molecules and ions move across the cell membrane by simple diffusion and by making use of specialized membrane components (channels, carriers, and pumps). The text emphasizes the quantitative aspects of such movement and its interpretation in terms of transport kinetics. Molecular studies of channels, carriers, and pumps are described in detail as well as structural principles and the fundamental similarities between the various transporters and their evolutionary interrelationships. The regulation of transporters and their role in health and disease are also considered.
ChaptersStructural Basis of Movement Across Cell MembranesSimple Diffusion of Nonelectrolytes and IonsIon Channels Across Cell MembranesCarrier-Mediated Transport: Facilitated DiffusionCoupling of Flows of Substrates: Antiporters and SymportersPrimary Active Transport SystemsThe Regulation and Integration of Transport SystemsAppendicesSingle and Triple-Letter Codes for the Amino AcidsFundamental Constants, Conversion Factors, and Some Useful ApproximationsThe Relation between the Permeability Coefficient Ps and the Half-Time t1/2 of Entry of a Permeant
Subject Areas: Botany & plant sciences [PST], Biochemistry [PSB]
