Cerebral Microbleeds
Pathophysiology to Clinical Practice

A definitive, systematic summary of knowledge and research into brain microbleeds - an important imaging marker for small vessel disease.

David J. Werring (Edited by)

9780521198455, Cambridge University Press

Hardback, published 26 May 2011

198 pages, 85 b/w illus.
25.3 x 19.5 x 1.5 cm, 0.6 kg

'Cerebral Microbleeds: Pathophysiology to Clinical Practice is a 198-page textbook that covers the entire current state of knowledge on microbleeds, ranging from the historical perspective to current imaging methods and histopathology … David Werring has succeeded in assembling virtually all authorities on cerebral microbleeds to share their knowledge and views on this emerging topic. This has yielded a comprehensive overview that is of interest both to the uninitiated student wanting to know what all the fuss is about and to the more experienced neuroscientist working in the field of cerebral small vessel disease.' The Lancet

Stroke is a leading cause of death and disability throughout the world. About one in three symptomatic strokes are due to disease of small perforating arteries; however, most effective interventions are targeted at disease of large arteries. The underlying mechanisms and treatment of small vessel disease remain poorly understood. Microbleeds have emerged as a critical imaging marker of small vessel disease, being found in all types of stroke. With increasing evidence that microbleeds are caused by hypertensive arteriopathy and cerebral amyloid angiopathy, they are likely to play a strong future role in increasing our understanding of the causes of small vessel disease and the potential link between cerebrovascular disease and neurodegeneration. Cerebral Microbleeds summarizes our current knowledge, bringing together expert research from global authorities in the field. This authoritative and systematic text will be of interest to all clinical researchers and physicians in the fields of stroke and cognitive impairment.

Preface
Foreword Vladimir Hachinski
A short note on terminology
Part I. Historical Aspects, Detection and Interpretation: 1. Historical overview: microaneurysms, cerebral microbleeds and intracerebral hemorrhage Varinder Singh Alg and David J. Werring
2. Detection of microbleeds – physical principles, technical aspects and new developments Maarten J. Versluis, Andrew G. Webb and Mark A. van Buchem
3. Susceptibility-weighted imaging E. Mark Haacke, Alexander S. Boikov, Samuel Barnes, Jaladhar Neelavalli and M. Ayaz Khan
4. Defining and mapping cerebral microbleeds Simone M. Gregoire and David J. Werring
5. Microbleed mimics Neshika Samarasekera, Gillian Potter and Rustam Al-Shahi Salman
Part II. Mechanisms Underlying Microbleeds: 6. Histopathology of cerebral microbleeds Sebastian Brandner
7. Risk factors for cerebral microbleeds Lenore J. Launer
8. Relationship of cerebral microbleeds to other imaging findings Eric E. Smith, David J. Werring and Cheryl R. McCreary
Part III. Microbleeds in Relation to Specific Populations, Diseases and Neurological Symptoms: 9. Microbleeds in healthy populations Bo Norrving
10. Microbleeds in relation to cerebrovascular disease Seung-Hoon Lee and Jae-Kyu Roh
11. Microbleeds in relation to hypertensive arteriopathy Eric E. Smith and Roland N. Auer
12. Microbleeds in relation to cerebral amyloid angiopathy M. Ayaz Khan, Anand Viswanathan and Steven M. Greenberg
13. Cerebral microbleeds and Alzheimer's disease Charlotte Cordonnier and Wiesje M. van der Flier
14. Cerebral microbleeds in relation to brain trauma Rainer Scheid
15. Cerebral microbleeds in CADASIL Anand Viswanathan, Hugues Chabriat and Martin Dichgans
16. Miscellaneous conditions associated with cerebral microbleeds David J. Werring and Hans Rolf Jäger
17. Cerebral microbleeds and cognitive impairment David J. Werring and Mike O'Sullivan
18. Other clinical manifestations of cerebral microbleeds Simone M. Gregoire and David J. Werring
19. Cerebral microbleeds and antithrombotic treatment Yannie O. Y. Soo and Lawrence K. S. Wong
20. Cerebral microbleeds and thrombolysis Chelsea S. Kidwell
Index.

Subject Areas: Medical imaging [MMP], Pathology [MMF], Neurology & clinical neurophysiology [MJN]