Cellular Biophysics and Modeling
A Primer on the Computational Biology of Excitable Cells

What every neuroscientist should know about the mathematical modeling of excitable cells, presented at an introductory level.

Greg Conradi Smith (Author)

9781107005365, Cambridge University Press

Hardback, published 14 March 2019

394 pages, 21 b/w illus. 248 colour illus. 6 tables
25.3 x 17.8 x 2.4 cm, 0.92 kg

'In this text, Conradi Smith does an excellent job of teaching students with no mathematical training beyond calculus how to use differential equations to understand the basic principles of cell physiology and excitability. He skilfully walks students through the steps of modeling and analysis, all the while working to develop intuition and insight into how things work. His emphasis on computational methods for solution as well as graphical and geometrical means for interpretation enables him to communicate complex ideas in understandable ways. Furthermore, his patience and attention to detail will be appreciated by those students who have not had extensive exposure to the art of mathematical modeling. This text is a wonderful addition to the mathematical biology textbook literature.' James P. Keener, University of Utah

What every neuroscientist should know about the mathematical modeling of excitable cells. Combining empirical physiology and nonlinear dynamics, this text provides an introduction to the simulation and modeling of dynamic phenomena in cell biology and neuroscience. It introduces mathematical modeling techniques alongside cellular electrophysiology. Topics include membrane transport and diffusion, the biophysics of excitable membranes, the gating of voltage and ligand-gated ion channels, intracellular calcium signalling, and electrical bursting in neurons and other excitable cell types. It introduces mathematical modeling techniques such as ordinary differential equations, phase plane, and bifurcation analysis of single-compartment neuron models. With analytical and computational problem sets, this book is suitable for life sciences majors, in biology to neuroscience, with one year of calculus, as well as graduate students looking for a primer on membrane excitability and calcium signalling.

1. Introduction
Part I. Models and Odes: 2. Compartmental modeling
3. Phase diagrams
4. Ligands, receptors and rate laws
5. Function families and characteristic times
6. Bifurcation diagrams of scalar ODEs
Part II. Passive Membranes: 7. The Nernst equilibrium potential
8. The current balance equation
9. GHK theory of membrane permeation
Part III. Voltage-Gated Currents: 10. Voltage-gated ionic currents
11. Regenerative ionic currents and bistability
12. Voltage-clamp recording
13. Hodgkin-Huxley model of the action potential
Part IV. Excitability and Phase Planes: 14. The Morris-Lecar model
15. Phase plane analysis
16. Linear stability analysis
Part V. Oscillations and Bursting: 17. Type II excitability and oscillations
18. Type I excitability and oscillations
19. The low-threshold calcium spike
20. Synaptic currents.

Subject Areas: Cellular biology [cytology PSF], Neurosciences [PSAN], Biophysics [PHVN], Mathematical physics [PHU], Statistical physics [PHS], Nonlinear science [PBWR], Mathematical modelling [PBWH], Cellular physiology [MFGC], Physiology [MFG], Physiological & neuro-psychology, biopsychology [JMM]