Cell Therapy
Stem Cell Transplantation, Gene Therapy, and Cellular Immunotherapy

Examines the current state and future prospects of haematopoietic cell therapy, including gene therapy and immunotherapy.

George Morstyn (Edited by), William Sheridan (Edited by)

9780521473156, Cambridge University Press

Hardback, published 29 March 1996

647 pages, 71 b/w illus. 5 colour illus. 34 tables
23.5 x 15.7 x 3.5 cm, 1.02 kg

'… an excellent and timely text … strongly recommended …'. N. H. Russell, The Lancet

Cell therapy is a rapidly developing area, drawing on cell biology, molecular biology, virology, immunology, cell quantitation techniques and biomedical engineering. It has potential in many clinical settings, in the treatment of cancer and other diseases. This volume in the series Cancer: Clinical Science in Practice examines the current state and future prospects of cell therapy, which seems likely to have an even more profound impact on health care than did the production of proteins by recombinant DNA technology. The coverage is broad, including the scientific principles of haematopoietic cell therapy, the technology of cell collection and preparation, current and likely future clinical applications of cell therapy, and the principles and practice of cellular immunotherapy. Up-to-date and authoritative, volumes in this series are intended for a wide audience of clinicians and researchers with an interest in the applications of biomedical science to the understanding and management of cancer.

Part I. Aspects of Hematopoiesis: 1. Overview of hematopoiesis and review of cells needed for hematopoietic reconstitution
2. Review of cells important for adoptive cellular immunotherapy
3. Potential uses of defined cell populations
4. Progenitor cell assays
5. Flow cytometric techniques
6. Principles of gene therapy
7. Sources of progenitor cells
8. Chemotherapy approaches to mobilization of progenitor cells
9. Cytokine approaches to mobilization of progenitor cells
10. Stem cell isolation
11. Methods of cell selection using monoclonal antibodies
12. Magnetic approaches to cell separation
13. Growth factors and ex-vivo expansion of hematopoietic progenitor cells
14. Bioreactors for expansion
15. Purging of malignant cells
Part II. Current Clinical Approaches: 16. What can be achieved without cell therapy
17. Clinical potential of hematopoietic growth-factor support for high-dose chemotherapy
18. Review of high-dose chemotherapy requiring cellular support in solid tumors
19. Review of high-dose chemotherapy requiring cellular support in hematological malignancies
20. Review of the potential use of cell therapy in leukemia
Part III. Future Clinical Applications: 21. Clinical gene therapy
22. Correction of inborn errors
23. Cellular therapy approaches to the treatment of AIDS
Part IV. Experimental and Clinical Cellular Immunotherapy: 24. Adoptive immunotherapy with T cells
25. Cellular adoptive immunotherapy with natural killer cells
26. Autologous tumor cell vaccines
27. Allogeneic cellular vaccines against tumors
28. Neutrophil transfusions for treatment of infections
29. Experimental and clinical cellular immunotherapy in bone-marrow transplantation
30. Donor lymphocyte therapy in bone-marrow transplantation
31. Graft-versus-leukemia effect in bone-marrow transplantation.

Subject Areas: Haematology [MJF]