Cell Surface GRP78, a New Paradigm in Signal Transduction Biology

Provides an overview of our understanding of the role of GRP78 as a major factor in cancer and other malignancies

Salvatore V. Pizzo (Edited by)

9780128123515, Elsevier Science

Paperback, published 22 March 2018

144 pages
22.9 x 15.1 x 1.1 cm, 0.25 kg

Cell Surface GRP78, a New Paradigm in Signal Transduction Biology presents a new paradigm that has emerged in the past decade with the discovery that various intracellular proteins may acquire new functions as cell surface receptors. Two very prominent examples are ATP synthase and GRP78. While the role of cell surface ATP synthase has been reviewed in various books, this book directs its attention to the story of cell surface GRP78.

1. Introduction to the Discovery of the Endoplasmic Reticulum Chaperone GRP78 on the Cell Surface 2. The Endoplasmic Reticulum Chaperone GRP78 also Functions as a Cell Surface Signaling Receptor 3. Cell surface GRP78: Anchoring and Translocation Mechanisms and Therapeutic Potential in Cancer 4. Cell Surface GRP78: A Targetable Marker of Cancer Stem-like Cells 5. Cell Surface GRP78 Regulates the Pro-Coagulant Activity of Tissue Factor 6. GRP78 Modulates the Plasminogen Activating System in the Brain: Implications for Human Disease 7. Escherichia coli Subtilase Cleaves Cell Surface GRP78 preventing COOH-terminal Signaling

Subject Areas: Cellular biology [cytology PSF], Molecular biology [PSD], Life sciences: general issues [PSA]