Cell Polarity in Development and Disease

Offers insights into the basic molecular mechanisms of diseases that arise as a result of a loss of ordered organization and intrinsic polarity

Douglas W Houston (Edited by)

9780128024386

Paperback / softback, published 2 November 2017

236 pages, 75 full color
22.9 x 15.1 x 1.6 cm, 0.39 kg

Cell Polarity in Development and Disease offers insights into the basic molecular mechanisms of common diseases that arise as a result of a loss of ordered organization and intrinsic polarity. Included are diseases affecting highly polarized epithelial tissues in the lung and kidney, as well as loss and gain of cell polarity in the onset and progression of cancer. This book provides a basic resource for understanding the biology of polarity, offering a starting point for those thinking of targeting cell polarity for translational medical research.

1. Overview of cell polarity: insights from model organisms and cellular systems
2. Cell polarity in the egg and early embyro- mammal
3. Pluripotency and cell polarity
4. The role of cell polarity in adult stem cell maintenance
5. Integration of cell polarity and growth factor signaling
6. Cell polarity and the onset and progression of cancer
7. Cell division and cell polarity
8. Polarized membrane/vesicle trafficking and disease
9. Polarized microtubule transport and disease
10. Regulation of cell polarity in cell/neuronal migration
11. Apical and planar cell polarity in ciliated epithelia
12. Renal epithelial cell polarity and disease
13. Hepatic cell polarity and disease
14. Epidermal cell polarity and disease
15. Cell polarity and sensory cell defects

Subject Areas: Cellular biology [cytology PSF]