Caveolae and Lipid Rafts: Roles in Signal Transduction and the Pathogenesis of Human Disease

The first book available dedicated to caveolae in human diseases and cellular metabolism

Edward Bittar (Edited by), Philippe Frank (Guest editor), Michael Lisanti (Guest editor)

9780444515001, Elsevier Science

Hardback, published 7 October 2005

264 pages, Illustrated
22.9 x 15.1 x 2.2 cm, 0.58 kg

Caveolae (latin for little caves) are small structures found at the surface of cells. They are responsible for the regulation of important metabolic pathway. As a consequence, they may play a critical role in several human diseases such as atherosclerosis, cancer, diabetes, and muscular dystrophies. This book analyzes the role and function of caveolae in these aspects and serves as the first textbook currently available on caveolae/caveolin.

Section 1: Caveolae organization and role in lipid cholesterol metabolism.
Lipid rafts and caveolae organization.
Caveolae and the regulation of cellular cholesterol homeostasis.
Section 2: Caveolae and the regulation of endocytosis.
The Caveolae Internalization Machinery.
Lipid raft mediated entry of bacteria into host cells.
Section 3: Examples of the role of caveolins in cell signaling.
The caveolin interaction with the endothelial nitric oxide synthase (eNOS).
Caveolae and Estrogen Receptor Signaling.
eNOS regulation by sphingosine 1-phosphate and caveolin.
Insulin signaling and caveolae.
Section 4: Caveolae and pathologies.
Caveolin-3, Caveolae, and Hereditary Muscle Diseases.
Caveolae and Caveolins in the Vascular System.
Caveolin Proteins in Cardio-pulmonary Disease and Lung Cancers.

Subject Areas: Cellular biology [cytology PSF], Molecular biology [PSD], Biophysics [PHVN]