Carbonic Anhydrases
Biochemistry and Pharmacology of an Evergreen Pharmaceutical Target

Provides a step-by-step approach and introduction to carbonic anhydrases, spanning biochemical and structural features, pharmacology, and more

Claudiu T. Supuran (Edited by), Alessio Nocentini (Edited by)

9780128164761

Paperback, published 18 July 2019

560 pages, 50 illustrations (20 in full color)
23.4 x 19 x 3.5 cm, 1.06 kg

Carbonic Anhydrases provides an interdisciplinary review of the burgeoning carbonic anhydrase (CA) research area, spanning from CAs classification (biochemical and structural features) to drug design and pharmacology of CA inhibitors and activators, finally touching on the biotechnological applications of these metalloenzymes. The book adopts a clear step-by-step approach and introduction to this intricate and highly interdisciplinary field. A diverse range of chapters from international experts speak to CA classification and distribution, the mechanisms of action and drug design of inhibitors and activators, the druggability of the various isoforms in the treatment of a multitude of diseases, and threats to human health.

1. Carbonic Anhydrases: An Overview
2. a-Carbonic Anhydrases
3. ß-Carbonic Anhydrases
4. ?-Carbonic Anhydrases
5. d-Carbonic Anhydrases
6. ?-Carbonic Anhydrases
7. ? and ?-Carbonic Anhydrases
8. Human Carbonic Anhydrases: Tissue Distribution, Physiological Role and Druggability
9. Mechanisms of Action of Carbonic Anhydrase Inhibitors: Zinc Binders
10. Mechanisms of Action of Carbonic Anhydrase Inhibitors: Compounds That Anchor to The Zinc-Bound Nucleophile
11. Mechanisms of Action of Carbonic Anhydrase Inhibitors: Compounds Occluding the Entrance of The Active Site
12. Mechanisms of Action of Carbonic Anhydrase Inhibitors: Compounds That Bind “Out of The Binding Site? And Compounds with An Unknown Mechanism of Action
13. Carbonic Anhydrase Inhibitors as Ophthalmologic Drugs for The Treatment of Glaucoma
14. Carbonic Anhydrase Inhibitors as Diuretics
15. Carbonic Anhydrase Inhibitors for The Treatment of Epilepsy and Obesity
16. Carbonic Anhydrase Inhibitors for The Treatment of Tumors: Therapeutic, Immunologic, And Diagnostic Tools Targeting Isoforms IX And XII
17. Carbonic Anhydrase Inhibitors for The Treatment of Neuropathic Pain and Arthritis
18. Carbonic Anhydrases from Pathogens: Bacterial Cas And Their Inhibitors as Potential Anti-Infectives
19. Carbonic Anhydrases from Pathogens: Fungal Cas And Their Inhibitors as Potential Antifungal Agents
20. Carbonic Anhydrases from Pathogens: Protozoan Cas And Related Inhibitors as Potential Anti-Protozoal Agents
21. Carbonic Anhydrase Activators and Their Potential in The Pharmaceutical Field
22. Biotechnological Applications of Carbonic Anhydrases from Extremophiles
23. CO2 Capture by Engineered Mammalian Carbonic Anhydrases

Subject Areas: Molecular biology [PSD], Enzymology [PSBZ]