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Cancer Genomics
From Bench to Personalized Medicine
Gain insight into the technological advances shaping studies, diagnosis and treatment of cancer.
Graham Dellaire (Edited by), Jason N Berman (Edited by), Robert J. Arceci (Edited by)
9780123969675, Elsevier Science
Hardback, published 15 January 2014
510 pages
27.6 x 21.5 x 3 cm, 1.61 kg
"…provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies." --Anticancer Research 34, 2014
Cancer Genomics addresses how recent technological advances in genomics are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. The dramatic increase in cancer genomics research and ever-increasing availability of genomic testing are not without significant ethical issues, which are addressed in the context of the return of research results and the legal considerations underlying the commercialization of genomic discoveries. Finally, the book concludes with "Future Directions", examining the next great challenges to face the field of cancer genomics, namely the contribution of non-coding RNAs to disease pathogenesis and the interaction of the human genome with the environment.
Introduction 1. Historical Overview Methodological Approaches and Background 2. Expression Arrays (SNPs, etc.) 3. Tissue micro-arrays (breast, ovarian) 4. Next generation sequencing (DNAseq) 5. RNAseq (breast cancer, sarcomas) 6. Epigenetic Analyses 7. Pharmcogenomics 8. Biomarker discovery through genomics 9. Preclinical models for genomics (cell culture, transgenic animals, xenografts) 10. Bioinformatics and computational methods for data analysis 11. Genomic Resource Projects – The Cancer Genome Atlas (TCGA) International Cancer Genome Consortium (ICGC) Ethics of Genomics Research 12. Ethics of Genomics Research The Genomics, Epigenomics and Transcriptomics of Cancer 13. Somatic mutations, Transcription and Epigenetics Overview Adult Solid Tumors 14. Lung Cancer 15. Breast Cancer 16. Prostate Cancer 17. Colon Cancer 18. Thyroid Cancer Age Non-specific Tumors and Hematopoietic Malignancies 19. ALL 20. AML 21. NHL 22. Multiple Myeloma 23. Brain Tumors Pediatric Cancers 24. Neuroblastoma 25. Soft tissue sarcomas 26. Osteosarcoma 27. Wilms Tumors Germline Mutations and Hereditary Cancer Syndromes 28. Germline Mutations and Hereditary Cancer Syndromes Future Directions 29. The role of microRNAs and ultraconserved non-coding RNAs in cancer 30. Environmental impact on cancer genomics
Subject Areas: DNA & Genome [PSAK1], Oncology [MJCL], Medical genetics [MFN]
