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Cancer Consult
Expertise for Clinical Practice
Syed A. Abutalib (Edited by), SA Abutalib (Author), Maurie Markman (Edited by)
9781118589212, Wiley
Paperback / softback, published 22 August 2014
968 pages
27.9 x 21.6 x 3.8 cm, 2.413 kg
The field of oncology benefits from several large-scale reference books and a host of monographs dedicated to specific cancers. However, truly excellent practice and review books are, surprisingly, quite scarce. Outside of a scant handful of books and online reference tools that offer clinical response practice and board review in a basic question and answer format, there are no resources that offer a robust, engaging, fully referenced tool for these vital activities in every oncologist’s and oncology trainee’s work. This print and electronic book seeks to fill that void, offering comprehensive question-and-answer style content that covers the entire specialty of oncology and provides practicing oncologists with a fascinating and immediately applicable compendium of vital information dealing with a well-balanced selection of common and uncommon cancers. At the heart of this book is the editor’s and authors’ desire to overcome the controversies and barriers to practice that usually emerge following the appearance of new data. In every section, the user is guided toward collaboration in ongoing clinical research – for example, via discussions of well-designed ongoing clinical trials in each specific area. Developed with both the teacher and learner in mind, this book also offers trainees and fellows an excellent opportunity to enhance their preparation for the ABIM oncology fellowship exam as well as for the oncology boards. It will also be an extremely useful tool for oncologists working toward the recertification exam. This comprehensive, beefy book includes hundreds of painstakingly developed multiple-choice and mini-case-based questions covering the principles of medical oncology, malignant hematology, surgical oncology, and radiation oncology. It also contains mini-cases and questions dealing with the biology, diagnosis, classification, staging, and multidisciplinary treatment of cancers at every anatomic site. The very latest topics are included, such as molecular techniques, targeted therapies, and translational cancer research. Concise but detailed answers are referenced to key journals and books, and evidence-based wherever possible. NCCN guidelines are also referenced as appropriate. With its powerful focus on take-home messages from and for actual clinical work, this book will help keep oncologists up to date, bridging the gaps between journal and reference literature, conferences, and their existing knowledge base.
List of Contributors, x Preface, xxi Section 1 Malignant Hematology and Hematopoietic Cell Transplantation Part 1 Acute Lymphoblastic Leukemia in Adults 1 Diagnosis of acute lymphoblastic leukemia, 5 2 Prognostic markers and models in acute lymphoblastic leukemia, 18 3 Management of B-cell acute lymphoblastic leukemia, 22 4 Management of T-cell acute lymphoblastic leukemia, 29 5 Minimal residual disease in acute lymphoblastic leukemia, 35 6 Hematopoietic cell transplantation in adult acute lymphoblastic leukemia, 40 Part 2 Acute Myeloid Leukemia in Adults 7 Prognosis in acute myeloid leukemia: cytogenetics and beyond, 51 8 Induction therapy in acute myeloid leukemia, 58 9 Consolidation therapy in acute myeloid leukemia, 67 10 Management of acute promyelocytic leukemia, 71 11 Minimal residual disease in acute myeloid leukemia, 76 12 Relapsed and refractory acute myeloid leukemia, 82 13 Hematopoietic cell transplantation in acute myeloid leukemia, 89 Part 3 Myelodysplastic Syndromes and Related Disorders 14 Pitfalls in the diagnosis of myelodysplastic syndromes, 99 15 Cytogenetics and prognostic models in myelodysplastic syndromes, 106 16 Management of myelodysplastic syndromes, 113 17 Management of therapy-related myeloid neoplasms, 120 18 Hematopoietic cell transplantation in myelodysplastic syndromes, 126 19 Acquired aplastic anemia, 131 Part 4 Myeloproliferative Neoplasms 20 Diagnostic approach in myeloproliferative neoplasms, 137 21 Chronic myeloid leukemia: chronic phase, 142 23 Chronic myeloid leukemia and pregnancy, 150 24 Polycythemia vera, 152 25 Essential thrombocytosis, 156 26 Primary myelofibrosis, 162 27 Eosinophilic myeloproliferative disorders, 167 28 Chronic myelomonocytic leukemia, 176 29 Hematopoietic cell transplantation in chronic myeloid leukemia, 180 30 Hematopoietic cell transplantation in primary myelofibrosis, 187 Part 5 Chronic Lymphocytic and Other Leukemias 31 Prognostic markers and management of chronic lymphocytic leukemia, 195 32 Hematopoietic cell transplantation in chronic lymphocytic leukemia, 201 33 Prolymphocytic leukemia, 207 34 Hairy cell leukemia, 220 Part 6 Hodgkin Lymphoma 35 Management of classical Hodgkin lymphoma, 229 36 Nodular lymphocyte-predominant Hodgkin lymphoma, 235 37 Hematopoietic cell transplantation in Hodgkin lymphoma, 240 Part 7 Non-Hodgkin’s Lymphomas 38 Pitfalls in the diagnosis of non-Hodgkin’s lymphomas, 247 39 Follicular lymphoma, 257 40 Diffuse large B-cell lymphoma, 263 41 Mantle cell lymphoma, 270 42 Marginal zone lymphoma, 275 43 Primary mediastinal large B-cell lymphoma, 282 44 Burkitt lymphoma, 286 45 Gray zone lymphoma, 290 46 Transformed lymphoma, 295 47 HIV-associated lymphoma, 304 48 Primary CNS lymphoma, 308 49 Primary cutaneous lymphoma, 316 50 Mycosis fungoides and Sézary syndrome, 323 51 Hematopoietic cell transplantation in indolent non-Hodgkin’s lymphoma, 327 52 Hematopoietic cell transplantation in diffuse large B-cell lymphoma, 332 53 Hematopoietic cell transplantation in T-cell non-Hodgkin’s lymphomas, 339 Part 8 Plasma Cell Neoplasms and Related Disorders 54 Smoldering multiple myeloma and monoclonal gammopathy of undetermined significance, 347 55 Risk stratification and response assessment in multiple myeloma and Waldenström’s macroglobulinemia, 352 56 Treatment of multiple myeloma, 358 57 Light-chain amyloidosis, 366 58 Waldenström’s macroglobulinemia, 371 59 Autologous hematopoietic cell transplantation in multiple myeloma, 376 60 Allogeneic hematopoietic cell transplantation in multiple myeloma, 381 Part 9 Special Issues in Hematology 61 Role of PET scan in lymphomas, 391 62 Radioimmunotherapy in lymphomas, 398 63 Radiation oncology consultation for hematologic malignancies, 403 Part 10 Special Issues in Hematopoietic Cell Transplantation 64 Donor and graft selection in allogeneic hematopoietic cell transplantation, 411 65 Preparative regimens in allogeneic hematopoietic cell transplantation for malignant hematological 66 T-cell depletion in allogeneic hematopoietic cell transplantation, 421 67 Prevention and treatment of relapse following hematopoietic cell transplantation, 426 68 Acute graft-versus-host disease, 432 69 Chronic graft-versus-host disease, 438 Section 2 Oncology Part 1 Central Nervous System Tumors 70 Primary brain tumors, 449 71 Secondary brain and spinal cord tumors, 457 Part 2 Head and Neck Cancers and Thoracic Malignancies 72 Medical management of head and neck cancers, 467 73 Endocrine malignancies, 476 74 Methodological and practical challenges for personalized therapies in non-small-cell lung cancer, 480 75 Screening, staging, and stage I non-small-cell lung cancer, 486 76 Stage II and III non-small-cell lung cancer, 493 77 Recurrent and metastatic non-small-cell lung cancer and novel targets, 500 78 Small-cell lung cancer, 503 79 Mesothelioma, 506 Part 3 Breast Cancer 80 Immunohistochemistry testing and beyond in breast cancer, 515 81 Prevention and adjuvant therapy in breast cancer, 523 82 Preoperative systemic therapy for breast cancer, 532 83 Recurrent and metastatic breast cancer, 540 84 Special issues in the young and pregnant patient with breast cancer, 546 Part 4 Gastrointestinal Oncology 85 Early-stage esophageal and stomach cancers, 555 86 Metastatic esophagogastric cancer: controversies, consensus, and new targets, 562 87 Early-stage colorectal cancer, 567 88 Recurrent and metastatic colorectal cancer: controversies, consensus, and new targets, 573 89 Pancreatic cancer, 581 90 Hepatobiliary cancer, 590 91 Neuroendocrine tumors, 595 92 Transarterial liver-directed therapies in oncology, 601 93 Anal cancer, 606 Part 5 Genitourinary Oncology 94 Renal cancer: tumor diversity, molecular taxonomy, and prognostic algorithms, 615 95 Medical management of renal cancer, 621 96 Medical management of bladder cancer, 628 97 Prostate cancer: Screening, surveillance, prognostic algorithms and independent pathologic predictive 98 Medical management of prostate cancer, 638 99 Germ cell tumors, 645 Part 6 Skin Malignancies 100 Medical management of melanoma, 653 101 Nonmelanoma skin cancers, 661 PART 7 Gynecological Malignancies 102 Ovarian cancer: neoadjuvant, adjuvant, and surgical issues, 669 103 Ovarian cancer: second-line treatment strategies, 675 104 Endometrial and cervical cancers, 681 PART 8 Sarcomas 105 Bone sarcomas, 689 106 Soft tissue sarcomas, 696 PART 9 Multidisciplinary Approach: Consultation with Surgical Oncology Team 107 Surgical aspects of head and neck cancers, 707 108 Surgical aspects of thoracic malignancies, 711 109 Surgical aspects of upper gastrointestinal cancers, 719 110 Surgical aspects of pancreatic cancer, 723 111 Surgical aspects of hepatobiliary tumors, 729 112 Surgical aspects of lower gastrointestinal cancers, 735 113 Surgical aspects of renal cancer, 739 114 Surgical aspects of bladder cancer, 744 115 Surgical aspects of prostate cancer, 747 116 Surgical aspects of melanoma, 754 PART 10 Multidisciplinary Approach: Consultation with Radiation Oncology Team 117 Radiotherapy for head and neck cancers, 761 118 Radiotherapy for ductal carcinoma in situ (DCIS), 767 119 Radiotherapy for early-stage invasive breast cancer, 771 120 Radiotherapy for thoracic malignancies, 778 121 Radiotherapy for gastrointestinal malignancies, 785 122 Radiotherapy for genitourinary malignancies, 789 PART 11 Hereditary Cancer Syndromes and Genetic Testing in Oncology 123 When to suspect hereditary cancer syndromes, 795 124 Hereditary breast cancer syndromes, 800 125 Genetic testing in gastrointestinal tumors, 804 126 Hereditary urogenital cancer syndromes, 810 PART 12 Special Issues in Hematology and Oncology 127 Carcinoma of unknown primary (CUP), 817 128 Geriatric oncology, 822 129 Nuts and bolts of cancer immunotherapy, 826 130 Controversies related to oncology clinical trial development, 831 131 PET scan in oncology, 835 132 Hematopoietic growth factors, 841 133 Anticoagulation issues in oncology, 844 134 Symptom management and palliative care, 851 135 Metabolic and nutritional issues in oncology, 860 136 Bone-related issues in oncology, 867 137 Integrative medicine in oncology, 872 138 Naturopathic medicine in oncology, 879 139 Anesthesiology consultation for localized cancer pain, 884 140 Musculoskeletal care in oncology, 893 141 Cancer survivorship and psychosocial issues in oncology, 896 Index, 902 Color plate section facing p.522
Frederick G. Behm, Agatha Bogard, Syed A. Abutalib, and Sujata S. Gaitonde
Dieter Hoelzer
Hady Ghanem, Hagop Kantarjian, Nitin Jain, and Elias Jabbour
Daniel J. DeAngelo
Meir Wetzler
Netanel A. Horowitz and Jacob M. Rowe
Gordana Raca, Madina Sukhanova, and Lucy A. Godley
Tapan Kadia and Farhad Ravandi
Gregory K. Behbehani and Bruno C. Medeiros
Eytan M. Stein and Martin S. Tallman
Hans Beier Ommen, Line Nederby, Marie Toft-Petersen, Charlotte Guldborg Nyvold, and Peter Hokland
Stefan H. Faderl
Antonio M. Jimenez and Stefan O. Ciurea
Jay Yang, Gail Bentley, and Charles A. Schiffer
Uma Borate and Harry P. Erba
Vu H. Duong, Alan F. List, and Rami S. Komrokji
Jagoda K. Jasielec and Richard A. Larson
Antonio Di Stasi, Armin Ghobadi, and Partow Kebriaei
Valeria Visconte and Ramon V. Tiu
Ayalew Tefferi
Jerald P. Radich
22 Blast crisis of chronic myeloid leukemia, 147
Michael J. Mauro
Michael J. Mauro
Constantine S. Tam and Srdan Verstovsek
Paola Guglielmelli and Alessandro M. Vannucchi
Ayalew Tefferi
Jason Gotlib
Mrinal M. Patnaik
Jerald P. Radich
Irum Khan and Damiano Rondelli
Courtney D. DiNardo and Susan O’Brien
Michael R. Bishop
Claire Dearden
Justin M. Watts and Martin S. Tallman
Kristen Sanfi lippo and Nancy L. Bartlett
Dennis A. Eichenauer
Tsiporah Shore and Koen van Besien
Carmen Barcena and Laurence de Leval
Myron S. Czuczman
Andrew D. Zelenetz
Stephen Smith and John Sweetenham
Sarah Rutherford, Wayne Tam, and Peter Martin
Pier Luigi Zinzani
Mark Roschewski and Wyndham Wilson
Caron A. Jacobson and Ann S. LaCasce
Stephane Doucet and Jane N. Winter
Kieron Dunleavy
Nicholas A. Blondin, Joachim M. Baehring, and Fred H. Hochberg
Thomas M. Habermann
Stephane Dalle, Marie Perier-Muzet, Brigitte Balme, and Luc Thomas
Saurabh Chhabra and Ginna G. Laport
Syed A. Abutalib and Istvan Redei
Lori S. Muffly and Sonali M. Smith
Robert A. Kyle
Silvia Gentili and Sagar Lonial
Cindy Varga, Claudia Paba Prada, Kenneth Anderson, and Paul Richardson
David C. Seldin
Anita D’Souza and Morie A. Gertz
Jean-Luc Harousseau and Mohamad Mohty
Jasleen Randhawa, Veerpal Singh, and Parameswaran Hari
Matthew A. Lunning and James O. Armitage
Reem Karmali and Stephanie A. Gregory
Chris R. Kelsey and Leonard R. Prosnitz
Jose Leonel Ochoa-Bayona and Claudio Anasetti
diseases, 417
Robert J. Soiffer
Jenna D. Goldberg and Miguel-Angel Perales
Robert Chen, Sandra Thomas, and Stephen J. Forman
Andrew C. Harris and John E. Levine
Carrie L. Kitko and Daniel R. Couriel
Barbara J. O’Brien and Mark R. Gilbert
Rimas V. Lukas, Patrik Gabikian, and Steven J. Chmura
Tobenna Nwizu and David Adelstein
Ann W. Gramza
Ignacio I. Wistuba
Tarek M. Mekhail
Grzegorz Korpanty and Natasha B. Leighl
Evan Pisick and Ravi Salgia
Stephen V. Liu and Glen J. Weiss
Christopher W. Towe and Harvey I. Pass
Alejandro A. Gru and D. Craig Allred
Faithlore P. Gardner and Edith A. Perez
Virginia Kaklamani and William J. Gradishar
Dennis L. Citrin
Hatem A. Azim Jr. and Fedro A. Peccatori
M. Naomi Horiba and Yixing Jiang
Geoffrey Y. Ku and David H. Ilson
Vaibhav Sahai and Al B. Benson III
Davendra Sohal and Robert J. Pelley
Katherine Van Loon and Margaret Tempero
Keith Stuart
Anya Litvak and Leonard Saltz
Divyesh G. Mehta and Jeffery Choh
Rob Glynne Jones
Henry J. Conter and Eric Jonasch
Gary R. MacVicar and Timothy M. Kuzel
Gary R. MacVicar and Timothy M. Kuzel
parameters, 634
Megan G. Lockyer and Thomas M. Wheeler
Elizabeth K. O’Donnell and Philip Kantoff
Timothy Gilligan
Ana M. Ciurea and Kim Margolin
Daniel Christiansen and Anna Sancho Clayton
Alpa M. Nick and Robert L. Coleman
Maurie Markman
Maurie Markman
Nicole Larrier, William C. Eward, and Richard F. Riedel
Neeta Somaiah and Shreyaskumar Patel
Constance E.H. Teo and Randal S. Weber
Albert S.Y. Chang, Thomas A. D’Amico, and David C. White
Sabha Ganai and Mitchell C. Posner
Amanda B. Cooper, Ching-Wei D. Tzeng, and Matthew H.G. Katz
Subhasis Misra and Leonidas Koniaris
Anthony J. Senagore
Michael E. Woods and Matthew C. Raynor
Michael B. Williams
Peter Pinto
Thomas Velancia
Shiyu Song
Beryl McCormick
Julia White
Meredith E. Giuliani and Andrea Bezjak
Manisha Palta, Christopher Willett, and Brian Czito
Christina H. Chapman and Curtiland Deville
Emily Dalton and Kathy Schneider
Kathy Schneider and Emily Dalton
Kristen M. Shannon and Daniel C. Chung
Melanie Corbman and Eric Fowler
Isabella C. Glitza and Gauri R. Varadhachary
Nayana Kamath and Supriya Gupta Mohile
Christopher R. Heery and James L. Gulley
Elihu H. Estey
Shaunagh McDermott and Michael A. Blake
LeAnn B. Norris, Jametta Magwood, and Charles L. Bennett
Steven M. Corsello and Jean Marie Connors
Rony Dev and Eduardo D. Bruera
Julia Fechtner, Carolyn Lammersfeld, Carol Ireton-Jones, and Pankaj Vashi
S. Mujtaba Rizvi, Helen Collins, and Alan Lipton
Weidong Lu and David S. Rosenthal
Christina M. Shannon, Tracey Thomas, and Shauna Birdsall
Abed Rahman, Magdalena Anitescu, and Raed Rahman
James E. Rosenberg and Charles A. McDonald
Jabeen Abutalib, Shahid Raza, and Laura Sunn
Subject Areas: Clinical & internal medicine [MJ]
