Brain Norepinephrine
Neurobiology and Therapeutics

This book examines the anatomy, physiology, molecular biology, pharmacology and therapeutics of norepinephrine in the brain.

Gregory A. Ordway (Edited by), Michael A. Schwartz (Edited by), Alan Frazer (Edited by)

9780521834919, Cambridge University Press

Hardback, published 15 February 2007

662 pages
25.3 x 17.8 x 3.5 cm, 1.25 kg

Norepinephrine is a chemical neurotransmitter. Drugs that directly manipulate central nervous system (CNS) norepinephrine are being developed targeting noradrenergic neurons to deliver therapeutic effects. Noradrenergic drugs have been proven effective for depression and ADHD, and new disease indications are being identified. A team of experts provides the reader with a thorough understanding of the anatomy, physiology, molecular biology, pharmacology and therapeutics of norepinephrine in the brain, including an extensive review of the role of norepinephrine in brain diseases. The book is divided into four sections: the basic biology of norepinephrine; the role that norepinephrine plays in behavior; evidence of norepinephrine's role in CNS diseases, and the pharmacology and therapeutics of noradrenergic drugs in the treatment of psychiatric and neurological disorders.

Introduction: revision of an old transmitter Gregory A. Ordway
Part I. The Neurobiology of Norepinephrine: 1. Neuroanatomical and chemical organization of the locus coeruleus Kimberly L. Simpson and Rick C. S. Lin
2. Interactions of norepinephrine with other neurotransmitter systems: anatomical basis and pharmacology Craig A. Stockmeier and Gregory A. Ordway
3. Receptors for norepinephrine and signal transduction pathways David B. Bylund
4. Regulation of gene transcription in the central nervous system by norepinephrine Ronald S. Duman and Samuel S. Newton
5. The norepinephrine transporter and regulation of synaptic transmission Subbu Apparsundaram
Part II. Norepinephrine and Behavior: 6. Role of the locus coeruleus-norepinephrine system in arousal and circadian regulation of the sleep wake cycle Gary S. Aston-Jones, Monica Gonzalez and Scott Doran
7. Locus coeruleus and regulation of behavioral flexibility and attention: clinical implications Gary S. Aston-Jones, Michiyo Iba, Edwin Clayton, Janusz Rajkowski and Jonathan Cohen
8. Norepinephrine and long-term memory function Benno Roozendaal
9. Norepinephrine and stress David A. Morilak
Part III. The Biology of Norepinephrine in CNS Pathology: 10. Animal models of psychopathology: focus on norepinephrine Leonie A. M. Welberg and Paul Plotsky
11. Neuropathology of central norepinephrine in psychiatric disorders: postmortem research Gregory A. Ordway
12. Norepinephrine in mood disorders Pedro L. Delgado and Cristinel Coconcea
13. Noradrenergic pathology and pain Antti Pertovaara
14. Norepinephrine in cognitive disorders Amy F. T. Arnsten
15. Norepinephrine in neurological disorders Francesco Fornai
16. Genetics of noradrenergic neurobiology Inna Belfer and David Goldman
Part IV. Psychopharmacology of Norepinephrine: 17. Actions of antidepressant and other drugs on norepinephrine systems Elliott Richelson
18. The clinical role of norepinephrine antidepressants in depression and anxiety disorders J. Craig Nelson
19. Norepinephrine in attention deficit hyperactivity disorder Fred W. Riemherr, Michael A. Schwartz, B. K. Marchant and E. Higgins
20. Psychopharmacology of norepinephrine in eating disorders Katherine A. Halmi and Sun Young Yum
21. Role of norepinephrine in substance abuse Susan L. Broom and Bryan K. Yamamoto.

Subject Areas: Neurosciences [PSAN], Clinical psychology [MMJ], Psychiatry [MMH], Neurology & clinical neurophysiology [MJN]