Bound Carbohydrates in Nature

This 1994 book is a summary of Professor Waren's pivotal research on the special properties of bound carbohydrates in nature.

Leonard Warren (Author)

9780521447430, Cambridge University Press

Paperback, published 17 February 1994

128 pages, 30 b/w illus. 7 tables
21.5 x 13.9 x 0.8 cm, 0.173 kg

This 1994 book is based on a series of six lectures delivered at the University of Sienna under the auspices of the Lezioni Lincee. The content of the book reflects and delineates the author's career in biochemical research. The lectures revolve around the special role which bound carbohydrates play in nature. Also discussed are the properties of membrane glycoproteins, involved in the resistance of cells to drugs. The metabolism of sugars and sialic acids, which form a pivotal role in the author's research, are covered in detail. The book chronicles just some of the huge advances which have been made in biochemistry over the past few decades and will prove an invaluable and entertaining first hand account for researchers and graduate students.

1. Introduction, history, microheterogeneity of bound carbohydrates
function of bound carbohydrates
inducible changes in bound carbohydrates
programmed changes in bound carbohydrates
a possible role for bound carbohydrates
2. Sialic acids
distribution of sialic acids in nature
the metabolism of hexamines and sialic acids
metabolic control of hexosamines and sialic acids
asparagine N-glycosylation
processing of lysomal enzymes
biosynthesis of O-linked oligosaccarides
modification of sialic acids
sialidases
genetic metabolic disorders involving sialic acids, glycosidases, bound carbohydrates in malignancy
3. Multidrug resistance, properties of P-glycoprotein
lysomes and multidrug resistance
kinetics of influx and efflux of drugs, modulation of multidrug resistance
the role of lipids in the accumulation of drugs by MDR cells
P-170 and membrane lipids
Overview.

Subject Areas: Carbohydrates [PSBF], Organic chemistry [PNN]