Biometals in Autism Spectrum Disorders

Comprehensive overview of trace metal biology in autism spectrum disorders and neurodevelopment

Andreas Grabrucker (Author)

9780128211328, Elsevier Science

Paperback, published 8 July 2020

222 pages
22.9 x 15.1 x 1.5 cm, 0.36 kg

Biometals in Autism Spectrum Disorders focuses on trace metals and autism. Compared to other references examining ASDs or metallomics, this book presents findings of abnormal metal homeostasis in ASD, providing an overview of current findings on trace metal biology, its role in ASD etiology, and how abnormal trace metal biology may be a common factor of several genetic and non-genetic causes of ASDs that were once considered unrelated. This comprehensive resource opens new vistas for the development of new therapies based on the targeted manipulation of trace metal homeostasis that will generate new awareness surrounding trace metal levels during pregnancy.

1. Introduction to Metallomics: The Science of Biometals2. Measuring Biometals3. The history of metals in autism spectrum disorders4. Essential trace metals and their function in brain development5. Non-essential metals and their brain pathology6. Biometals and nutrition in Autism Spectrum Disorders7. Linking trace metal abnormalities to Autism - insights from epidemiological studies8. The specific role of zinc in Autism Spectrum Disorder9. Animal models for trace metal abnormalities - links to Autism10. Animal models for Autism - links to biometals abnormalities11. Human stem cell models linking biometals abnormalities and Autism12. Extracerebral biometals in Autism Spectrum Disorders: the gut-brain axis13. Biometal homeostasis as therapeutic strategy in Autism Spectrum Disorders14. Future perspectives: Autism, a disorder of biometal imbalance?

Subject Areas: Toxicology [non-medical PSBT], Neurosciences [PSAN], Child & developmental psychology [JMC]