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Biomedical Hydrogels
Biochemistry, Manufacture and Medical Applications
Steve Rimmer (Edited by)
9780081017418, Elsevier Science
Paperback / softback, published 19 August 2016
288 pages
23.3 x 15.6 x 1.9 cm, 0.4 kg
"…the book is the perfect lead for researchers interested in hydrogels to be applied for biomedical purposes. It offers a comprehensive overview of the complete route a hydrogel should follow going from developmental stage to clinical application and legislation." --Biomat.net, March 2014
Hydrogels are very important for biomedical applications because they can be chemically manipulated to alter and control the hydrogel’s interaction with cells and tissues. Their flexibility and high water content is similar to that of natural tissue, making them extremely suitable for biomaterials applications. Biomedical hydrogels explores the diverse range and use of hydrogels, focusing on processing methods and novel applications in the field of implants and prostheses. Part one of this book concentrates on the processing of hydrogels, covering hydrogel swelling behaviour, superabsorbent cellulose-based hydrogels and regulation of novel hydrogel products, as well as chapters focusing on the structure and properties of hydrogels and different fabrication technologies. Part two covers existing and novel applications of hydrogels, including chapters on spinal disc and cartilage replacement implants, hydrogels for ophthalmic prostheses and hydrogels for wound healing applications. The role of hydrogels in imaging implants in situ is also discussed. With its distinguished editor and international team of contributors, Biomedical hydrogels is an excellent reference for biomedical research scientists and engineers in industry and academia, as well as others involved in research in this area, such as research clinicians.
Part I: Processing of hydrogels Chapter 1: Hydrogel swelling behavior and its biomedical applications Abstract: 1.1 Basics of hydrogels 1.2 Swelling of hydrogels: water diffusion into hydrogels 1.3 Stimulus-responsive hydrogels 1.4 Examples of environment-sensitive hydrogels 1.5 Future trends Chapter 2: Superabsorbent cellulose-based hydrogels for biomedical applications Abstract: 2.1 Introduction 2.2 Cellulose-based hydrogels and crosslinking strategies 2.3 Hydrogel properties and thermodynamics 2.4 Applications 2.5 Conclusions Chapter 3: Synthesis of hydrogels for biomedical applications: control of structure and properties Abstract: 3.1 Introduction 3.2 Cross-linking of high molecular weight polymers 3.3 Copolymerization with multi-functional monomers 3.4 Multiphase hydrogels 3.5 Functional hydrogels 3.6 Conclusion Chapter 4: Processing and fabrication technologies for biomedical hydrogels Abstract: 4.1 Introduction 4.2 Applications 4.3 Gelation 4.4 Physical crosslinking 4.5 Photopolymerization and photopatterning 4.6 Stereolithography 4.7 Two-photon laser scanning photolithography 4.8 Processing of multicomponent hydrogels 4.9 Future trends 4.10 Acknowledgements Chapter 5: Regulation of novel biomedical hydrogel products Abstract: 5.1 Introduction 5.2 Regulatory jurisdictions 5.3 Regulatory frameworks 5.4 Risk-based device classification 5.5 Non-clinical testing 5.6 Clinical data and studies 5.7 Marketing authorization processes 5.8 Quality system requirements 5.9 Post-market requirements 5.10 Future trends 5.11 Sources of further information and advice Part II: Applications of hydrogels Chapter 6: Spinal disc implants using hydrogels Abstract: 6.1 Introduction 6.2 Intervertebral disc 6.3 Disc implant 6.4 Conclusion Chapter 7: Hydrogels for intraocular lenses and other ophthalmic prostheses Abstract: 7.1 Introduction 7.2 Intraocular lenses 7.3 Vitreous substitutes 7.4 Tissue adhesives 7.5 Conclusions 7.5 Acknowledgements Chapter 8: Cartilage replacement implants using hydrogels Abstract: 8.1 Introduction 8.2 Historical background in cartilage repair and injury: existing therapies 8.3 First and second generation tissue engineering 8.4 Third generation tissue engineering 8.5 Future trends Chapter 9: Hydrogels for wound healing applications Abstract: 9.1 Introduction 9.2 Requirements of an ideal wound care system 9.3 Hydrogels for wound healing applications 9.4 Natural hydrogels for wound healing applications 9.5 Synthetic and other hydrogels for wound healing applications 9.6 Commercial dressings 9.7 Future trends 9.8 Conclusion 9.10 Appendix: list of abbreviations Chapter 10: Imaging hydrogel implants in situ Abstract: 10.1 Introduction 10.2 Rationale for imaging implants in situ 10.3 Imaging modalities and their advantages and disadvantages for the in situ imaging of hydrogel implants 10.4 Challenges of imaging in situ 10.5 Contrast enhancement 10.6 Characterization of implants (in vitro and in vivo) 10.7 Characterization of in vivo healing 10.8 Conclusions 10.9 Sources of further information and advice Index
Subject Areas: Materials science [TGM], Biotechnology [TCB], Biomedical engineering [MQW], Medical equipment & techniques [MBG]
