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Biomedical Applications of Functionalized Nanomaterials
Concepts, Development and Clinical Translation
Explains how functionalized nanomaterials are engineered and used in biomedicine
Bruno Sarmento (Edited by), Jose Das Neves (Edited by)
9780323508780, Elsevier Science
Paperback / softback, published 3 March 2018
778 pages
23.4 x 19 x 4.7 cm, 0.45 kg
Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation presents a concise overview of the most promising nanomaterials functionalized with ligands for biomedical applications. The first section focuses on current strategies for identifying biological targets and screening of ligand to optimize anchoring to nanomaterials, providing the foundation for the remaining parts. Section Two covers specific applications of functionalized nanomaterials in therapy and diagnostics, highlighting current practice and addressing major challenges, in particular, case studies of successfully developed and marketed functionalized nanomaterials. The final section focuses on regulatory issues and clinical translation, providing a legal framework for their use in biomedicine. This book is an important reference source for worldwide drug and medical devices policymakers, biomaterials scientists and regulatory bodies.
Introduction: From the "magic bullet" to advanced nanomaterials: An historical perspective Part I. Ligand selection and functionalization of nanomaterials1. Phage display technology for screening antibody fragments2. Bioengineered approaches for site-orientation of peptide-based ligands of nanomaterials3. Engineered protein variants for bioconjugation4. Engineering of nanozymes for biomedical applications5. Strategies for the functionalization of mesoporous nanomaterials for biomedical use6. Systematic evolution of ligands by exponential enrichment (SELEX) for aptamer selection7. Biological methodologies for assessment of functionality of nanomaterials Part II. Specific applications of functionalized nanomaterials in therapy and diagnostics8. Functionalized graphene-based materials for bioimaging applications9. Multifunctional magnetic nanoparticles for theranostic applications10. Stimuli-sensitive grafting polymers for targeted anticancer drug delivery 11. Functional moieties for intracellular traffic of nanomaterials12. Biofunctionalized mesoporous silica nanomaterials for nuclei targeting13. Lipid-derived nanoparticles for targeted delivery of siRNA14. Aptamer-siRNA nanoparticles for targeted anti-HIV therapeutics15. Peptide and protein self-assembled nanofibers for vaccine development and immunotherapy16. Functional biomaterials for vascular tissue engineering17. Functionalized hydrogels for culture and delivery of cells Part III. Manufacturing, regulatory challenges and clinical testing of functionalized nanomaterial-based products18. Manufacturing and safety guidelines for the manufactured functional nanomaterials19. Challenges for planning clinical trials of functionalized nanomaterials20. Clinical testing of ACCURINS® therapeutics: challenges and lessons learned
Subject Areas: Biotechnology [TCB], Nanotechnology [TBN], Biomedical engineering [MQW]
