Freshly Printed - allow 10 days lead
Couldn't load pickup availability
Biomaterials for Cancer Therapeutics
Diagnosis, Prevention and Therapy
Kinam Park (Edited by)
9780857096647
Hardback, published 21 October 2013
530 pages
23.4 x 15.6 x 3.1 cm, 0.94 kg
"On the whole, the book is a combination of the fundamentals of cancer biology, guiding principles on the design of biomaterials and the clinical potential of these biomaterials, which is of interest to a broad audience involving chemists, biologist and material scientists." --Biomat.net, June 2014 "Intended for researchers, this collection introduces new methods for delivering drugs to cancer cells and tumors and innovative technologies for treating cancers with biomaterials. Needham …describes his low temperature-sensitive liposome (Thermodox) drug delivery system, which failed to meet its primary endpoint in a phase III trial of liver cancer." --ProtoView.com, February 2014
Cancer can affect people of all ages, and approximately one in three people are estimated to be diagnosed with cancer during their lifetime. Extensive research is being undertaken by many different institutions to explore potential new therapeutics, and biomaterials technology is now being developed to target, treat and prevent cancer. This unique book discusses the role and potential of biomaterials in treating this prevalent disease.
The first part of the book discusses the fundamentals of biomaterials for cancer therapeutics. Chapters in part two discuss synthetic vaccines, proteins and polymers for cancer therapeutics. Part three focusses on theranosis and drug delivery systems, whilst the final set of chapters look at biomaterial therapies and cancer cell interaction.
This extensive book provides a complete overview of the latest research into the potential of biomaterials for the diagnosis, therapy and prevention of cancer. Biomaterials for cancer therapeutics is an essential text for academics, scientists and researchers within the biomedical industry, and will also be of interest to clinicians with a research interest in cancer therapies and biomaterials.
Contributor contact details Woodhead Publishing Series in Biomaterials Preface Chapter 1: Introduction to biomaterials for cancer therapeutics Abstract: 1.1 Introduction 1.2 Biomaterials used in cancer therapeutics 1.3 Materials used in anticancer formulations 1.4 Conclusion and future trends Chapter 2: Cancer cell biology Abstract: 2.1 Introduction 2.2 Public perception and misunderstanding of cancer cell activity 2.3 The ‘War on Cancer’ 2.4 The genetic basis of cancer 2.5 Cancer interface with the environment 2.6 Cancer cells as moving targets 2.7 Conclusion and future trends Chapter 3: Targeted drug delivery for cancer therapy Abstract: 3.1 Introduction 3.2 Current paradigm 3.3 Challenges to current paradigm 3.4 Conclusion and future trends Chapter 4: Chemical synthesis of carbohydrate-based vaccines against cancers Abstract: 4.1 Introduction 4.2 Semi-synthetic vaccines 4.3 Fully synthetic vaccines 4.4 Conclusion and future trends Chapter 5: Generating functional mutant proteins to create highly bioactive anticancer biopharmaceuticals Abstract: 5.1 Introduction 5.2 Artificial proteins for cancer therapy 5.3 How to create functional mutant proteins as beneficial therapeutics 5.4 Mutant TNF? for cancer therapy 5.5 Conclusion and future trends 5.6 Sources of further information and advice Chapter 6: Polymer therapeutics for treating cancer Abstract: 6.1 Introduction 6.2 Polyamines and polyamine analogs 6.3 Polymeric P-glycoprotein (Pgp) inhibitors 6.4 Conclusion and future trends 6.5 Acknowledgment Chapter 7: Nanotechnology for cancer screening and diagnosis Abstract: 7.1 Introduction 7.2 Nanotechnology for cancer diagnosis 7.3 Nanotechnology-based biosensing platforms 7.4 Nanotechnology for biosensing – early detection of cancer 7.5 Nanotechnology for cancer imaging 7.6 Concerns with using nanomaterials 7.7 Conclusion and future trends Chapter 8: Synergistically integrated nanomaterials for multimodal cancer cell imaging Abstract: 8.1 Introduction 8.2 Nanomaterial-based multifunctional imaging probes 8.3 Nanoparticles with exogenous imaging ligands 8.4 Nanoparticles with endogenous contrast 8.5 Cocktail injection 8.6 Conclusion Chapter 9: Hybrid nanocrystal as a versatile platform for cancer theranostics Abstract: 9.1 Introduction 9.2 Imaging modality 9.3 Developing theranostic systems 9.4 Hybrid nanocrystal as theranostic platform 9.5 Conclusion 9.6 Acknowledgment Chapter 10: Embolisation devices from biomedical polymers for intra-arterial occlusion drug delivery in the treatment of cancer Abstract: 10.1 Introduction 10.2 Biomedical polymers and embolisation agents 10.3 Particulate embolisation agents 10.4 Drug-eluting embolisation beads 10.5 Polymer structure, form and property relationships 10.6 Experience with drug-eluting embolisation beads 10.7 Conclusions and future trends 10.8 Acknowledgement Chapter 11: Small interfering RNAs (siRNAs) as cancer therapeutics Abstract: 11.1 Introduction 11.2 Prerequisites for siRNAs cancer therapeutics 11.3 Delivery systems for anticancer siRNAs 11.4 Current challenges for clinical trials 11.5 Conclusion 11.6 Acknowledgement Chapter 12: Reverse engineering of the low temperature-sensitive liposome (LTSL) for treating cancer Abstract: 12.1 Introduction 12.2 What is reverse engineering? 12.3 Investigating the thermal-sensitive liposome’s performance-in-service 12.4 Defining the function of the liposome 12.5 Component design: mechanism of action 12.6 Selecting the most appropriate material when designing the Dox-LTSL 12.7 Analysis of materials performance in the design 12.8 Specification sheet 12.9 Production 12.10 Prototypes 12.11 Further development 12.12 Conclusion and future trends 12.13 Acknowledgements Chapter 13: Gold nanoparticles (GNPs) as multifunctional materials for cancer treatment Abstract: 13.1 Introduction 13.2 Physical properties of gold nanoparticles 13.3 Surface chemistry of GNPs 13.4 GNPs as vehicles for drug delivery 13.5 GNPs in biomedical imaging and theranostics 13.6 GNPs as radiosensitizing agents 13.7 Challenges in the development of GNPs as therapeutic agents 13.8 Conclusion and future trends 13.9 Acknowledgments Chapter 14: Multifunctional nanosystems for cancer therapy Abstract 14.1 Introduction 14.2 Design of multifunctional nanosystems 14.3 Illustrative examples of multifunctional nanosystems for tumor-targeted therapies 14.4 Polymeric nanosystems 14.5 Lipid nanosystems 14.6 Hybrid nanosystems 14.7 Regulatory and clinical perspectives 14.8 Conclusions Chapter 15: Biomaterial strategies to modulate cancer Abstract: 15.1 Introduction 15.2 Understanding cancer with biomaterials 15.3 Molecular markers for cancer 15.4 Biomaterials for cancer therapy 15.5 Conclusion Chapter 16: 3D cancer tumor models for evaluating chemotherapeutic efficacy Abstract: 16.1 Introduction 16.2 Efforts to fight cancer 16.3 Preclinical drug evaluation in cellular and animal models 16.4 In vivo environment 16.5 2D vs 3D culture systems 16.6 3D tumor models 16.7 Methods to culture multicellular tumor spheroids 16.8 Conclusion Chapter 17: Nanotopography of biomaterials for controlling cancer cell function Abstract: 17.1 Introduction 17.2 The influence of surface topography and roughness of PLGA on cancer cells: creation of nanoscale PLGA surfaces 17.3 The influence of nanoscale PLGA topographies on surface wettability and surface free energy 17.4 The influence of PLGA nanotopographies on protein adsorption 17.5 The impact of PLGA surface nanopatterns on cancer cell functions 17.6 The impact of nanopatterns and LBL monolayers on cell functions 17.7 Conclusions Index
Subject Areas: Materials science [TGM], Biomedical engineering [MQW], Oncology [MJCL]
