Biomaterials for 3D Tumor Modeling

Reviews the fundamentals and latest advances in research on 3D cancer models, focusing on biomaterials science, tissue engineering, drug delivery and screening

Subhas C. Kundu (Edited by), Rui L. Reis (Edited by)

9780128181287, Elsevier Science

Paperback, published 20 August 2020

772 pages, 260 illustrations (80 in full color)
23.4 x 19 x 4.7 cm, 1.47 kg

Biomaterials for 3D Tumor Modeling reviews the fundamentals and most relevant areas of the latest advances of research of 3D cancer models, focusing on biomaterials science, tissue engineering, drug delivery and screening aspects. The book reviews advanced fundamental topics, including the causes of cancer, existing cancer models, angiogenesis and inflammation during cancer progression, and metastasis in 3D biomaterials. Then, the most relevant biomaterials are reviewed, including methods for engineering and fabrication of biomaterials. 3D models for key biological systems and types of cancer are also discussed, including lung, liver, oral, prostate, pancreatic, ovarian, bone and pediatric cancer.

1. Trends in biomaterials for 3D cancer modeling 2. Causes of cancers: physical, chemical, biological carcinogens and viruses 3. Three-dimensional in vitro models of angiogenesis 4. Metastasis in 3D biomaterials 5. Biomatrices that mimic the cancer extracellular environment 6. Marine derived biomaterials for cancer treatment 7. 3D scaffold materials for skin cancer modeling 8. Three-dimensional tumor model and their implication in drug screening for tackling chemoresistance 9. In vitro 3D modelling for prostate cancer 10. Biomaterial based in vitro models for pancreatic cancer 11. Mesoporous silica nanoparticles for cancer theranostics applications 12. Microfluidic systems in cancer research 13. Bio-detection and sensing for cancer diagnostics 14. Biomaterials as ECM-like matrices for 3D in vitro tumor models 15. 3D cancer spheroids and microtissues 16. Co-culture and 3D tumor models for drug and gene therapy testing 17. Engineering of 3D in vitro models for cancer research 18. Tissue engineered 3D cancer microenvironment for screening therapeutics 19. 3D neuroblastoma models using engineered cell-derived matrices 20. 3D cancer models for chemotherapy using biomaterials 21. 3D tumor-on-chip devices with perfusion for anti-cancer drug testing 22. A predictive oncology framework: Modelling tumor proliferation using a FEM platform 23. Understanding the impact of controlled oxygen delivery to 3D cancer cell culture 24. 3D full skin models for skin cancer research 25. Tissue engineering strategies for treatment of skeletal maxillofacial defects resulting from neoplasms resections 26. 3D culture systems as models for solid tumors and cancer metabolism 27. Biofabrication of 3D tumor models in cancer research 28. Engineering breast cancer models in vitro with 3D printing

Subject Areas: Materials science [TGM], Biotechnology [TCB], Biochemistry [PSB], Biophysics [PHVN], Biomedical engineering [MQW]