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Biomarkers
In Medicine, Drug Discovery, and Environmental Health
Vishal S. Vaidya (Edited by), VS Vaidya (Author), Joseph V. Bonventre (Edited by)
9780470452240, Wiley
Hardback, published 27 October 2010
640 pages
24.3 x 16.4 x 3.7 cm, 1.061 kg
"In summary, this book provides an excellent introduction and overview of discovery and application of biomarkers in medicine and drug discovery and development. The chapters are well structured, with plenty of literature references for further reading, and supplemented with links to web-based resources." (ChemMedChem, 2011) "They cover tools for discovering biomarkers, biomarkers for injury or disease, technology for detecting biomarkers, and hot topics in biomarker research." (SciTech Book News, December 2010)"This book provides an introduction to the field of biomarkers, how they have been and can be used, and how different approaches can be used to identify, characterize, and monitor biomarkers." (News Blaze, 1 November 2010)
This book provides an introduction to the field of biomarkers, how they have been and can be used, and how different approaches can be used to identify, characterize, and monitor biomarkers. The book has chapters on topics including HIV, Cancer, Parkinson’s, vascular injury, environmental exposure. A following section discusses the technologies (diagnostics and assays) to detect biomarkers and authors have emphasized the preclinical and clinical manifestation of the injury/disease process.
Preface xxii Contributors xxv 1 Biomarkers: An Evolutionary Perspective 1 Section I: Tools for Biomarker Discovery 5 2 Genomics 7 3 Proteomics for Biomarker Discovery 25 4 Metabolic Profiling for Biomarker Discovery 47 5 The Bittersweet Promise of Glycobiology 75 Section II: Biomarkers of Injury/Disease 89 6 Biomarkers of Alzheimer's and Parkinson's Disease 91 7 Biomarkers of Cardiac Injury 119 8 Lung Injury Biomarkers 157 9 Translational Biomarkers of Acute Drug-Induced Liver Injury: The Current State, Gaps and Future Opportunities 203 10 Biomarkers of Acute Kidney Injury 237 11 In Search of Biomarkers for Drug-Induced Vascular Injury 281 12 Biomarkers of Immunotoxicity 307 13 Biomarkers in Obstetric Medicine 323 14 Biomarkers in Cancer 355 15 Biomarkers of HIV 381 16 Biomarkers of in Vitro Drug-Induced Mitochondrial Dysfunction 401 Section III: Technology for Biomarker Detection 423 17 Immunoassay-Based Technologies for the Measurement of Biological Materials Used for Biomarkers Discovery and Translational Research 425 18 Nanoscale Techniques for Biomarker Quantification 457 19 Immunodiagnostics with a Focus on Lateral Flow Point-of-Care Devices 495 Section IV: Hot Topics In Biomarker Research 517 20 Biomarkers for Environmental Exposure 519 21 Clinical Study Design in Biomarker Research 549 22 Statistical Issues in Biomarker Research 561 23 Regulatory Perspective for Biomarker Qualification from U.S. FDA 581 24 The European Medicines Agency Approach 589 Index 595
Michael Ferguson and Vishal Vaidya
Weida Tong and Donna L. Mendrick
Timothy D. Veenstra
Hector C. Keun
Padmaparna Chaudhuri, Rania Harfouche, and Shiladitya Sengupta
Walter Maetzler and Daniela Berg
Anthony S. McLean and Stephen J. Huang
Urmila P. Kodavanti
Josef Ozer, William Reagan, Sheli Schomaker, Joe Palandra, Mike Baratta and Shashi Ramaiah
Frank Dieterle and Frank Sistare
James R. Turk
Rodney R. Dietert
Manish Maski, Sarosh Rana and S. Ananth Karumanchi
Roopali Roy, Christine M. Coticchia, Jiang Yang and Marsha A. Moses
Lewis Kaufman and Michael J Ross
James A. Dykens and Yvonne Will
Vincent Ricchiuti
Madhukar Varshney, and Harold G. Craighead
Roy R. Mondesire, Glen M. Ford, Hannie F. Ford, and Stephen C. Mefferd
Jane E. Gallagher, Elaine A. Cohen Hubal and Stephen W. Edwards
Orfeas Liangos and Bertrand L. Jaber
Daniel Holder and Matthew Schipper
Federico Goodsaid
Marisa Papaluca Amati and Spiros Vamvakas
Subject Areas: Chemistry [PN]
