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Biology of Archaea 2
Molecular Biology of Archaea, From Genome Maintenance to the Regulation of Gene Expression
Béatrice Clouet-d'Orval (Edited by), Béatrice Clouet–d′Orval (Author), Bruno Franzetti (Edited by), Bruno Franzetti (Author), Philippe Oger (Edited by), Philippe Oger (Author)
9781789451696, Wiley
Hardback, published 8 July 2025
256 pages
23.5 x 15.6 x 1.7 cm, 0.47 kg
Archaea constitute a new branch of life alongside bacteria and eukaryotes. These microorganisms are unique in their cellular and molecular aspects. They have evolutionary links with the first eukaryotic cells and are now being used to elucidate fundamental biological questions. Champions of extremophilicity, archaea are helping to lift the veil on the limits of life on Earth. Biology of Archaea 2 presents the diverse molecular mechanisms involved in the fundamental processes of genome maintenance and regulation of gene expression in archaeal cells. This book analyzes the complex machinery involved in chromosome replication, DNA repair, RNA synthesis (transcription) and protein synthesis (translation), and explores the different classes of RNAs and enzymes involved in RNA maturation and degradation. These regulate the stability of messenger and regulatory non-coding RNAs, and contribute to the formation of the mature forms of ribosomal RNAs and transfer RNAs. These molecular mechanisms are closely related to those of eukaryotes.
Preface xi Chapter 1. Replication of Archaeal Chromosomes 1 1.1. Replication initiation 2 1.2. The elongation phase of replication 8 1.3. Okazaki fragment maturation 10 1.4. Restarting replication forks 15 1.5. Replication termination 18 1.6. Chromosome segregation and decatenation 18 1.7. References 19 Chapter 2. Archaeal DNA Repair 25 2.1. General introduction 25 2.2. Several different types of DNA damages occur in archaea 28 2.3. Different archaeal DNA repair pathways 31 2.4. Coordination of the different pathways by the replication clamp 40 2.5. Summary and conclusion 42 2.6. References 43 Chapter 3. Transcription in Archaea 45 3.1. RNA polymerase 47 3.2. The three stages of transcription 51 3.3. Transcription regulation 64 3.4. References 66 Chapter 4. RNA Classes and Their Maturation and Degradation Enzymes 77 4.1. Introduction 77 4.2. RNA classes in archaea 79 4.3. Ribonuclease families in archaea 84 4.4. Ubiquitous RNA-binding proteins in archaea 95 4.5. Conclusion 100 4.6. References 100 Chapter 5. Ribosome and Transfer RNA Biogenesis 115 5.1. Ribosome biogenesis 116 5.2. Synthesis and maturation of tRNAs 133 5.3. Methodical toolboxes 156 5.4. References 158 Chapter 6. The Diversity and Function of Noncoding RNAs in Archaea 167 6.1. Introduction 167 6.2. Noncoding RNA diversity 168 6.3. ncRNA identification 178 6.4. Circularization of noncoding RNAs 182 6.5. Conclusion 185 6.6. References 186 Chapter 7. Translation in Archaea 193 7.1. Initiating the translation 195 7.2. Elongation peptide synthesis 206 7.3. Translation termination and ribosome recycling 214 7.4. Conclusion 219 7.5. References 220 List of Authors 233 Index 237
Béatrice CLOUET-D'ORVAL, Bruno FRANZETTI and Philippe OGER
Ghislaine HENNEKE, Roxane LESTINI, Marc NADAL and Didier FLAMENT
Caroline L'HERMITTE-STEAD, Anaïs BAYARD, Alexey ALEKSANDROV, Roxane LESTINI and Hannu MYLLYKALLIO
Thomas FOUQUEAU, Duy KHANH PHUNG and Ludovic SAUGUET
Manon BATISTA, Béatrice CLOUET-D'ORVAL and Marie BOUVIER
Tamara BASTA and Sébastien FERREIRA-CERCA
Hubert F. BECKER and Christine GASPIN
Emmanuelle SCHMITT and Yves MECHULAM
Subject Areas: Clinical & internal medicine [MJ]
