Biology and Pathology of Trophoblast

An in-depth 2006 account of trophoblast: the tissue derived from the fertilised egg that nourishes and protects the developing foetus.

Ashley Moffett (Edited by), Charlie Loke (Edited by), Anne McLaren (Edited by)

9781107403154, Cambridge University Press

Paperback / softback, published 18 August 2011

294 pages
24.4 x 17 x 1.6 cm, 0.47 kg

"Readers who want a more scientific treatise on the wonders of the placenta should peruse Biology and Pathology of Trophoblast...provide succinct yet comprehensive introductions to a number of important immunologic concepts pertinent to the process of placentation and the maintenance of pregnancy. Many interesting facts about placental immunology are shared."
Drucilla J. Robers, M.D., Massachusetts General Hospital, New England Journal of Medicine.

Originally published in 2006, this book provides an in-depth account of trophoblast: the tissue derived from the fertilised egg that nourishes and protects the developing fetus. The cells of the trophoblast have many unique qualities, and exhibit great variability across different species. It has a fascinating role in the development of the placenta and as a regulator during early growth of the embryo. These aspects are all fully covered as well as studies on why it is not rejected by the mother as 'foreign' tissue. Disorders of trophoblast during development also manifest themselves in several clinical conditions during pregnancy, including gestational trophoblastic disease and pre-eclampsia. From stem cells through to epigenetics, implantation and X-chromosome inactivation, there is a lot to be learned about trophoblast, this volume provides a detailed summary of knowledge regarding the subject.

Preface Charlie Loke
Chair's introduction Anne McLaren
1. Trophoblast cell fate specification: discussion James Cross
2. Stem cells: pluripotency and extraembryonic differentiation in the mouse Tilo Kunath
3. Epigenetic regulation of trophoblast development P. Hajkova, S. E. Erhardt and M. A. Surani
4. Regulation of X chromosome inactivation in relation to lineage allocation in early mouse embryogenesis Neil Brockdorff
5. Gestational Trophoblastic disease R. A. Fisher and N. J. Sebire
6. Trophoblast and the first trimester environment Graham J. Burton, Eric Jauniaux
7. Implantation is a sticky situation Olga Genbacev, Akraporn Prakobphol, Russell A. Foulk and Susan J. Fisher
8. Trophoblast regulation of maternal endocrine function and behaviour E. B. Keverne
9. Molecular signalling in embryo-uterine interactions during implantation S. K. Dey and Susanne Tranguch
10.Trophoblast and pre-eclampsia C. W. G. Redman, I. L. Sargent and E. A. Linton
11. Trophoblast and uterine mucosal leukocytes Ashley Moffett
12. Immunology of trophoblast: a reappraisal Charlie Loke.

Subject Areas: Developmental biology [PSC], Neonatal medicine [MJWN], Materno-fetal medicine [MJTF], Gynaecology & obstetrics [MJT], Reproductive medicine [MFKC]