Biological Kinetics

This book demonstrates how an understanding of biological kinetics can lead to knowledge about the biological model being examined.

Lee A. Segel (Edited by)

9780521391849, Cambridge University Press

Hardback, published 9 January 1992

232 pages
23.7 x 15.7 x 1.7 cm, 0.468 kg

"...a first rate introduction to, or review of, methods for analyzing biological kinetic data....can be read by either mathematically or biochemically trained scientists. Both groups will gain a better understanding of the other's work." Carla Wofsy, Mathematical Biosciences

As interest in theoretical biology grows, so does the need for an accessible link between these theories and experiments. The central purpose of this book is to illustrate the premise that examination of the kinetics of biological processes can give valuable information concerning the underlying mechanisms that are responsible for these processes. Topics covered range from co-operativity in protein binding, through receptor-infector coupling, to theories of biochemical oscillations in yeast and slime mould. In addition, an introduction to the explosively growing theoretical topic of chaos details attempts to apply this theory in physiology. The material of this book originally appeared as part of the volume Mathematical Models in Molecular and Cellular Biology (edited by L. A. Segel). However each article has been revised and updated.

Preface
Fundamental concepts in biochemical reaction theory
Equilibrium binding of macromolecules with ligands
Allosteric and induced-fit theories of protein binding
Positive and negative cooperativity
Graphical representations for tetramer binding
Enzyme induction
Molecular models for receptor to adenylate cyclase coupling
Models for oscillations and excitability in biochemical systems
Control of neurotransmitter release: use of facilitation to analyze the regulation of intracellular calcium
Acceptable and unacceptable models of liver regeneration in the rat
Chaos
Index.

Subject Areas: Mathematical modelling [PBWH]