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Biological Identification
DNA Amplification and Sequencing, Optical Sensing, Lab-On-Chip and Portable Systems
A detailed description of cutting-edge detection systems and methods for pathogens, toxins, and bioterrorism agents
R. Paul Schaudies (Edited by)
9780857095015
Hardback, published 7 May 2014
470 pages
23.3 x 15.6 x 2.9 cm, 0.85 kg
"A veritable encyclopedia of some of the latest advances in technology and procedures for biological detection and analysis." --Dr. John Vitko, former Director of the Chemical and Biological Defense Division of the Science and Technology Directorate of the Department of Homeland Security
Biological Identification provides a detailed review of, and potential future developments in, the technologies available to counter the threats to life and health posed by natural pathogens, toxins, and bioterrorism agents. Biological identification systems must be fast, accurate, reliable, and easy to use. It is also important to employ the most suitable technology in dealing with any particular threat. This book covers the fundamentals of these vital systems and lays out possible advances in the technology. Part one covers the essentials of DNA and RNA sequencing for the identification of pathogens, including next generation sequencing (NGS), polymerase chain reaction (PCR) methods, isothermal amplification, and bead array technologies. Part two addresses a variety of approaches to making identification systems portable, tackling the special requirements of smaller, mobile systems in fluid movement, power usage, and sample preparation. Part three focuses on a range of optical methods and their advantages. Finally, part four describes a unique approach to sample preparation and a promising approach to identification using mass spectroscopy. Biological Identification is a useful resource for academics and engineers involved in the microelectronics and sensors industry, and for companies, medical organizations and military bodies looking for biodetection solutions.
Part I: Technology for DNA and RNA analysis of pathogens 1. Nucleic acid sequencing for characterizing infectious and/or novel agents in complex samples 2. Multiplexed, lateral flow, polymerase chain reaction (PCR) techniques for biological identification 3. Isothermal amplification of specific sequences 4. Bead array technologies for genetic disease screening and microbial detection Part II: Lab-on-chip and portable systems for biodetection and analysis 5. Electrochemical detection for biological identification 6. Conductometric biosensors 7. Bio-chem-FETs: field effect transistors for biological sensing 8. Microfluidic devices for rapid identification and characterization of pathogens Part III: Optical systems for biological identification 9. Optical biodetection using receptors and enzymes (porphyrin-incorporated) 10. Overview of terahertz spectral characterization for biological identification 11. Raman spectroscopy for biological identification 12. Lidar (Light Detection And Ranging) for biodetection Part IV: Sample preparation and mass spectrometry-based biological analysis 13. Electrophoretic approaches to sample collection and preparation for nucleic acids analysis 14. Mass spectrometry-based proteomics techniques for biological identification
Subject Areas: Biosensors [TCBS], Molecular biology [PSD], DNA & Genome [PSAK1]
