Freshly Printed - allow 7 days lead
Couldn't load pickup availability
Biocalorimetry 2
Applications of Calorimetry in the Biological Sciences
John E. Ladbury (Edited by), JE Ladbury (Author), Michael L. Doyle (Edited by)
9780470849682, Wiley
Hardback, published 16 July 2004
288 pages
24.8 x 17.4 x 2.1 cm, 0.652 kg
"...an excellent review of the subject..." (Chromatographia, Vol 62 (7/8) October 2005) "…recommended to researchers working on thermal analysis in the fields of biochemistry ... pharmacy due to the abundance of practical advice." (Engineering of Life Sciences, 2006)
Als Nachfolger der Erstauflage, erscheint jetzt "Biocalorimetry 2".
Dieser neue Band trägt den jüngsten Fortschritten auf dem Gebiet der Biokalorimetrie Rechnung.
Behandelt werden alle Neuerungen in den Bereichen Ausrüstung, Anwendung und Methodologie.
Diskutiert werden auch Neuentwicklungen bei der Messung kleiner Proben und bei Hochdurchsatzverfahren.
Mittlerweile gehören hochempfindliche Kalorimeter in den meisten Labors zur Standardausrüstung. Sie werden benutzt, um biomolekulare Wechselwirkungen zwischen Wirkstoffen, Proteinen und Nucleinsäuren zu untersuchen sowie die DNA- und die Proteinstabilität zu messen.
Mit ausführlichen experimentellen Protokollen.
Geschrieben von führenden Experten auf diesem Gebiet.
"Biocalorimetry 2" ist ein unverzichtbares Nachschlagewerk zur Biokalorimetrie.
Preface. List of Contributors. PART I: GENERAL INTRODUCTION. 1. Applications of Biocalorimetry: Binding, Stability and Enzyme Kinetics (R. O’Brien and I. Haq). PART II: ISOTHERMAL TITRATION CALORIMETRY. 2. Isothermal Titration Calorimetry: A Tutorial (J.A. Thomson and J.E. Ladbury). 3. The Application of Isothermal Titration Calorimetry to Drug Discovery (G. Holdgate. S. Fisher and W. Ward). 4. Dissecting the Thermodynamics of DNA-Protein Interactions (T. Härd). 5. Salt Effects in Ribonuclease-Ligand Interactions: Screening or Competitive Binding? (K.P. Murphy, T.T. Waldron and G.L. Schrift) 6. Thermodynamic-Structure Correlations of Sulfonamide Inhibitor Binding to Carbonic Anhydrase (D. Matulis and M. Todd). 7. Energetics of the Interaction of Human Acidic Fibroblast Growth Factor with Heparin and the Functional Analog Myo-inositol Hexasulfate (M. Guzmán-Casado, M.M. Garcia-Mira, P. Cano-Soldado, J.M. Sanchez-Ruiz and A. Parody-Morreale). 8. Thermodynamics of SH2 Domain Binding (G. Waksman, S. Kumaran and P. Lubman). 9. Titration Calorimetry as a Tool to Determining Thermodyanmic and Kinetic Parameters of Enzymes (M.L. Bianconi). PART III: DIFFERENTIAL SCANNING CALORIMETRY. 10. Energetics of Site-Specific DNA Recognition by Integrase Tn916 (S. Milev, H.R. Bosshard and I. Jelesarov). 11. Linkage Between Temperature and Chemical Denaturant Effects on Protein Stability: The Intepretation of Calorimetrically-Determined m Values (B. Ibarra-Malero, R. Perez-Jimenez, R. Godoy-Ruiz and J.M. Sanchez-Ruiz). 12. Thermodymic Indications of the Molten Globule State of Cytochrome c Induced by Hydrophobic Salts (A.A. Moosavi-Movahedi and J. Chamani). 13. Microcalorimetry as Applied to Psychrophilic Enzymes (S. D’Amico, D. Georlette, T. Collins, G. Feller and C. Gerday). 14. An Autosampling Differential Scanning Calorimeter for Study of Biomolecular Interactions (V. Plotnikov, A. Rochalski, M. Brandts, J.F. Brandts, S. Williston, V. Frasca and L.-N. Lin). Index.
Subject Areas: Biology, life sciences [PS]
