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Bioactive Lipid Mediators in Cardiopulmonary Pharmacology

Presents the latest information on bioactive lipid mediators and the vast array of signaling pathways that regulate physiological and pathophysiological responses

Darryl C Zeldin (Volume editor), John Seubert (Volume editor)

9780323950572, Elsevier Science

Hardback, published 25 May 2023

462 pages
22.9 x 15.1 x 2.9 cm, 0.45 kg

Bioactive Lipid Mediators in Cardiopulmonary Pharmacology, Volume 97 updates readers on topics surrounding Bioactive lipid mediators. These mediators are involved in a vast array of signaling pathways that regulate both physiological and pathophysiological responses. Chapters in this new release include Cyclooxygenases and Vascular Function, Cyclooxygenases and Platelet Function, Eicosanoids and Cardiomyopathies, Cytochrome P450 Bioactive Lipids in the Heart, Epoxide Hydrolase and Leukotoxin in the Heart and Lung, Role of cytochrome P450-epoxygenase and soluble epoxide hydrolase in the regulation of vascular response, Bioactive Lipids in Hypertension, Cytochrome P450 Metabolites and Angiogenesis, 20-Hydroxyeicosatetraenoic Acid and Vascular Function, and more.

Other critical sections cover Cytochrome P450 Eicosanoids and the Brain, Omega-3 Oxylipids, Resolvins, Lipoxins and Inflammation, Endocannabinoids as Bioactive Metabolites, and Oxylipins and Aspirin Exacerbated Respiratory Disease.

Preface

Darryl C. Zeldin and John Seubert

1. Bioactive lipids in hypertension

John D. Imig

2. Role of cytochrome P450-epoxygenase and soluble epoxide hydrolase in the regulation of vascular response

Mohammed A. Nayeem, Werner J. Geldenhuys and Ahmad Hanif

3. Cyclooxygenases, eicosanoids and platelets

Annalisa Bruno, Stefania Tacconelli, Annalisa Contursi, Patrizia Ballerini and Paola Patrignani

4. The roles of eicosanoids in myocardial diseases

Zuowen He and Dao Wen Wang

5. Cardioprotective mechanisms of cytochrome P450 derived oxylipins from ?-3 and ?-6 PUFAs

Christi Cho, Theresa Aliwarga, Alexandra M. Wiley and Rheem A. Totah

6. 20-Hydroxyeicosatetraenoic acid (20-HETE): Bioactions, receptors, vascular function, cardiometabolic disease and beyond

Jonathan V. Pascale, Alexandra Wolf, Yonaton Kadish, Danielle Diegisser, Melissa-Maria Kulaprathazhe, Danait Yemane, Samir Ali, Namhee Kim, David E. Baruch, Muhamad Afiq Faisal Bin Yahaya, Ercument Dirice, Adeniyi M. Adebesin, John R. Falck, Michal L. Schwartzman and Victor Garcia

7. Insights into the role of the resolvin D2-GPR18 signaling axis in cardiovascular physiology and disease

Matthew Spite and Gabrielle Fredman

8. Cytochrome P450-derived eicosanoids in brain: From basic discovery to clinical translation

Catherine M. Davis, Aseel H. Ibrahim and Nabil J. Alkayed

9. Lipid mediators generated by the cytochrome P450: Epoxide hydrolase pathway

Timo Frömel, Jiong Hu and Ingrid Fleming

10. Role of omega-3 and omega-6 endocannabinoids in cardiopulmonary pharmacology

Tiffany Y.-C. Tang, Justin S. Kim and Aditi Das

11. Oxylipins in nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD)

Kimberley Cousins, Chien-Chang Chen, Esha Sehanobish and Elina Jerschow

Subject Areas: Pharmacology [MMG]

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