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Biased Signaling in Physiology, Pharmacology and Therapeutics
The first book to cover biased signaling across several receptor types, this unique resource offers real-world examples and valuable insight on how to use this data to understand complex pharmacology
Brian J Arey (Edited by)
9780124114609
Hardback, published 7 July 2014
316 pages
23.4 x 19 x 2.4 cm, 0.75 kg
"...markedly contributes to our understanding of biochemical and cellular mechanisms of diseases that should result in improved therapies for treating diseases. I highly recommend this book to any scientists working in the field of receptor biology. Four Stars - Score: 91"- Doody's
Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective.
1. Introduction – Biased Signaling in Nature 2. The Role of Cell Background in Receptor Signaling 3. The Application of Signaling Bias to New Therapeutic Drug Therapy for 7 Transmembrane (G Protein-Coupled) Receptors: Quantifying Bias 4. Nuclear Hormone Receptors 5. Growth Factor Receptors 6. Ion Channels 7. Protein Conformational Dynamics in Pathophysiology 8. Biased Signaling in Therapeutics
Subject Areas: Animal physiology [PSVD], Therapy & therapeutics [MMZ], Pharmacology [MMG], Physiology [MFG], Cytology [MFCC]
