Beyond the Synapse
Cell-Cell Signaling in Synaptic Plasticity

This book provides insight into how intercellular signalling enables neurons to communicate beyond the synapse.

R. Douglas Fields (Edited by)

9781107411562, Cambridge University Press

Paperback / softback, published 29 November 2012

322 pages
24.6 x 18.9 x 1.7 cm, 0.58 kg

Review of the hardback: 'The whole work, with its glossy hard boards and excellent illustrations, is well produced. … This fine survey will tell you all you could wish to know about what goes on between the neurons.' Biologist

Formation of synapses and the changes in their connections during life are the basis for learning and memory and recovery from brain disease or injury. Much interest has been focused on how synapses function at the molecular level, while the cell-cell interactions controlling the formation receive far less attention. This book expands the scope of inquiry beyond the synaptic cleft to provide a comprehensive insight into how intercellular signalling enables neurons to communicate beyond the synapse, and to interact with other cells in the brain to alter synaptic connections appropriately. There are chapters devoted to consideration of glia, brain cells which have thus far been ignored in the majority of studies of learning and memory. Writing for academic researchers and professionals, contributors to this book reveal that there is much to learning and memory that lies beyond the synapse.

Introduction: Beyond the synapse R. Douglas Fields
Part I. Spanning Scales of Neural Plasticity: 1. Memory beyond the synapse Steven P. R. Rose
2. Between synapses and behavior: functional circuitry of the hippocampus Howard Eichenbaum
3. Widening the lens: Looking beyond the synapse for experience-driven brain plasticity Julie A. Markham, Aaron W. Grossman and William T. Greenough
4. Activity-dependent myelination R. Douglas Fields
5. Bipolar disorder: involvement of signaling cascades and AMPA receptor trafficking at synapses Jing Du, Jorge Quiroz, Peixiong Yuan, Carlos Zarate Jr and Husseini K. Manji
Part II. Novelty, Stress, and Hormones in Plasticity: 6. Sleep-dependent memory consolidation and reconsolidation Matthew P. Walker and Robert Stickgold
7. Consolidation and reconsolidation of Pavlovian fear conditioning: roles for intracellular signaling and extracellular modulation in memory storage Christopher Cain, Jacek Debiec and Joseph LeDoux
8. Emotional and cognitive reinforcement of rat hippocampal long-term potentiation requires different neuromodulatory systems Volker Korz and Julietta U. Frey
9. Estrogen and hippocampal synaptic plasticity Micael Foy, Michael Baudry and Richard Thompson
10. Steroid-induced hippocampal synaptic plasticity: sex differences and similarities Russell D. Romeo, Elizabeth M. Waters and Bruce S. McEwen
Part III. Cell-cell Signaling Molecules in Synaptic Plasticity: 11. MHC class I in activity-dependent structural and functional plasticity Lisa M. Boulanger
12. Cytokine induction of neuronal receptor trafficking: relevance to synaptic function and excitotoxicity Dmitri Leonoudakis, Steven P. Braithwaite, Michael S. Beattie and Eric C. Beattie
13. Neurotrophin signaling among neurons and glia during formation of synapses Sarina B. Elmariah, Ethan G. Hughes, Eun Joo Oh and Rita J. Balice-Gordon
14. Regulation of neurogenesis by neurotrophins: implications in hippocampus-dependent memory Bai Lu and Jay H. Chang
15. Focal adhesion-like processes underly induction of long-term potentiation in the Schaffer-collateral-CA1 region of hippocampus Richard G. LeBaron, Ruben V. Hernandez, Mary M. Navarro, James E. Orfila, Lisa R. Curry and Joe L. Martinez
16. Signaling to the nucleus in long-term memory Olena Bukalo and R. Douglas Fields
Part IV. Non-traditional Transmitters and Glia: 17. Diffusible hydrogen peroxide generated post-synaptically inhibits axonal dopamine release in striatum Marat V. Avshalumov, Jyoti Patel, Li Bao, Duncan G. MacGregor and Margaret E. Rice
18. D-serine as a novel glial neurotransmitter Asif K. Mustafa, Paul M. Kim and Solomon H. Snyder
19. Conversations between glia and neurons in the retina: modulation of neuronal excitability Eric A. Newman
20. Metabotropic glutamate receptors as a target for astrocytic control of inhibitory synaptic transmission in hippocampus Wing-song Liu, Qiwu Xu, Jian Kang and Maiken Nedergaard.

Subject Areas: Neurosciences [PSAN]