Basics of Chimeric Antigen Receptor (CAR) Immunotherapy

Provides insights into the basic concepts and design of CAR therapy

Mumtaz Y. Balkhi (Author)

9780128195734, Elsevier Science

Paperback, published 19 July 2019

92 pages
23.4 x 19 x 0.8 cm, 0.2 kg

Basics of Chimeric Antigen Receptor (CAR) Immunotherapy presents the latest on how T cell adoptive immunotherapy has progressed in its ultimate goal of curing metastatic malignant cancers. Recent clinical data obtained with checkpoint receptor blockade inhibitors and chimeric antigen receptor (CAR) therapy has been especially promising, thus generating renewed hope that we may be on the verge of finally curing cancer. Over the years, huge progress has been made in controlling several stage IV metastasized cancers through the clinical application of checkpoint receptor inhibitory drugs and CAR-Therapy that has seen unprecedented interest in the immunotherapy field.

1. An introduction to CAR immunotherapy2. Components and design of Chimeric Antigen Receptors (CARs)3. scFv cloning, vectors and CAR production in laboratory for preclinical application4. Production of CAR-T cells for clinical application5. Challenges and opportunities to improve CAR-TE cell therapy

Subject Areas: Immunology [MJCM]