Autophagy: Lower Eukaryotes and Non-Mammalian Systems, Part A

Molecular breakthroughs in autophagy have led scientists to discover connections to cancer, neurodegeneration and lifespan extension. This volume, along with Autophagy: Lower Eukaryotes, marks the seminal collection of methods in the burgeoning field of autophagy.

Daniel Klionsky (Volume editor)

9780123745484, Elsevier Science

Hardback, published 18 December 2008

808 pages
22.9 x 15.1 x 4.1 cm, 1.42 kg

This is the companion volume to Daniel Klionsky’s Autophagy: Lower Eukaryotes, which features the basic methods in autophagy covering yeasts and alternative fungi. Klionsky is one of the leading authorities in the field. He is the editor-in-chief of Autophagy. The November 2007 issue of Nature Reviews highlighted his article, “Autophagy: from phenomenology to molecular understanding in less than a decade.? He is currently editing guidelines for the field, with 230 contributing authors that will publish in Autophagy.Particularly in times of stress, like starvation and disease, higher organisms have an internal mechanism in their cells for chewing up and recycling parts of themselves. The process of internal “house-cleaning? in the cell is called autophagy – literally self-eating. Breakthroughs in understanding the molecular basis of autophagy came after the cloning of ATG1 in yeast. These ATG genes in yeast were the stepping stones to the explosion of research into the molecular analysis of autophagy in higher eukaryotes. In the future, this research will help to design clinical approaches that can turn on autophagy and halt tumor growth.

Subject Areas: Cellular biology [cytology PSF], Molecular biology [PSD], Biochemistry [PSB]