Autoimmune Neurological Disease

This book reviews autoimmune neurological disease, including such common conditions as multiple sclerosis, the Guillain Barre syndrome and myasthenia gravis.

Michael P. Pender (Author), Pamela A. McCombe (Author)

9780521461139, Cambridge University Press

Hardback, published 27 October 1995

388 pages, 1 table
22.9 x 15.2 x 2.5 cm, 0.74 kg

'… provides a good introduction to the subject … this text should be of interest to neurologists and students who look for concise and thorough information about neuroimmunological disorders.' A. J. Steck, European Neurology

This book provides a comprehensive, up-to-date and critical overview of the immunological aspects of autoimmune neurological disease. These diseases include common conditions such as multiple sclerosis, the Guillain-Barre syndrome and myasthenia gravis. The introductory chapters on antigen recognition and self-nonself recognition, and neuroimmunology, are followed by chapters on specific diseases. These are presented in a standardised format with sections on clinical features, genetics, neuropathology, pathophysiology, immunology and therapy. Each chapter has a concluding section which summarises key points and suggests directions for future research. Animal models of autoimmune neurological disease are also covered in detail because of their importance in understanding the human diseases. The book is suitable for clinicians and neurologists managing patients with these diseases, and for immunologists, neuroscientists and neurologists investigating the pathogenesis and pathophysiology of these disorders.

1. Antigen recognition and self-nonself discrimination Ian H. Frazer
2. An introduction to neuroimmunology
3. Experimental autoimmune encephalomyelitis
4. Multiple sclerosis
5. Acute disseminated encephalomyelitis
6. The stiff-man syndrome
7. Experimental autoimmune neuritis
8. The Guillain-Barre syndrome and motor dysfunction
9. Chronic inflammatory demyelinating polyradiculoneuropathy, multifocal motor neuropathy and paraproteinaemic neuropathy
10. Autoimmune diseases of the neuromuscular junction and other disorders of the motor unit
11. Inflammatory myopathies and experimental autoimmune myositis
12. Paraneoplastic neurological disorders
13. Neurological complications of connective tissue diseases and vasculitis
Index.

Subject Areas: Pathology [MMF], Neurology & clinical neurophysiology [MJN], Immunology [MJCM]