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Asthma and COPD
Basic Mechanisms and Clinical Management
Offers a truly translational presentation of airway diseases – from bench to bedside – illuminating the mechanisms, etiology, and pathogenesis of respiratory disease and then translating how these mechanisms affect patient conditions, treatment options, and effective therapies
Peter J. Barnes (Edited by), Jeffrey M. Drazen (Edited by), Stephen I. Rennard (Edited by), Neil C. Thomson (Edited by)
9780123740014, Elsevier Science
Hardback, published 10 November 2008
896 pages
27.6 x 21.5 x 4.4 cm, 2.26 kg
"...textbooks, such as the one discussed here, are all essential in shaping a necessary way forward to fight chronic respiratory diseases worldwide...At first it was a surprise to see that this impressive textbook covered both asthma and chronic obstructive pulmonary disease (COPD) in one volume. Asthma and COPD: Basic Mechanisms and Clinical Management is edited and written by prominent individuals who have done everything possible in the past to convey the message that asthma and COPD are two different diseases: that they are characterised by different risk factors; have a different pathophysiology; are characterised by clinical phenotypes that are distinctly different; require different therapeutic strategies; and probably pose very different challenges to the health-care system. Yet in this textbook they now provide a truly novel approach towards our understanding and perception of asthma and COPD...the combined approach set out in this book towards asthma and COPD is not so much the Dutch hypothesis revisited, rather it is a more than sensible approach to understanding the nature and the challenges of chronic respiratory diseases in general. Asthma and COPD provides a superb synthesis of the most up-to-date knowledge on obstructive airways diseases by leading experts in the field...The description of basic mechanisms is a particularly strong feature, but the reader also finds excellent chapters on the pathogenic mechanisms of asthma and COPD, a description of risk factors and triggers, and a clinically useful description of the clinical assessment of these frequent conditions...this textbook is a joy to browse through and to read; it is very well illustrated, and the tabulated material is truly educational...I hope that this book will become one of the major reference sources for information on asthma and COPD and that it might have the potential to serve a much wider medical community than respiratory textbooks usually do." --Klaus F. Rabe, The Lancet
Asthma and COPD: Basic Mechanisms and Clinical Management, Second Edition continues to provide a unique and authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it continues to be a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments.
1. Definitions, Epidemiology and Genetics of Asthma and COPD
2. Epidemiology
3. Natural History
4. Genetics of Asthma and COPD
5. Pulmonary Physiology
6. Airway Pathology
7. Airway Remodeling
8. Animal Models
9. Mast Cells and Basophils
10. Dentritic Cells
11. Macrophages
12. Eosinophils
13. Lymphocytes
14. Neutrophils
15. Fibroblasts
16. Epithelial Cells
17. Mucus and Mucin-Secreting Cells
18. Airway Smooth Muscle
19. Tracheobronchial Circulation
20. Pulmonary Vessels
21. Adhesion Molecules
22. Extracellular Matrix
23. Prostanoids
24. Leukotrienes and Lipoxins
25. Reactive Oxygen Species
26. Chemokines
27. Cytokines
28. Matrix Degrading Proteinases
29. Growth Factors,
30. Nitric Oxide
31. Transcription Factors
32. Neural and Humoral Control
33. Pathophysiology of Asthma
34. Pathogenesis of COPD
35. Allergens
36. Occupational Agents
37. Infections
38. Exercise as a Stimulus
39. Atmospheric Pollutants
40. Drugs
41. Diagnosis
42. Non-invasive Assessment of Airway Inflammation
43. Imaging
44. Systemic Manifestations
45. Cardiovascular Effects
46. Allergen Avoidance
47. Smoking Cessation
48. â2-adrenoceptor Agonists
49. Anticholinergic Bronchodilators
50. Theophylline
51. Corticosteroids
52. Mediator Antagonists
53. Antibiotics
54. Long-term Oxygen Therapy
55. Immunomodulators
56. Pulmonary Vasodilators
57. Ventilator Support
58. Pulmonary Rehabilitation
59. Surgery and Other Mechanical Interventions
60. Other Therapies
61. Future Therapies
62. Health Economics
63. Management of Chronic Asthma in Adults
64. Asthma Exacerbations
65. Childhood Asthma
66. Treatment for Stable COPD
67. Acute Exacerbations of COPD
68. Education and Self-Management
Subject Areas: Medical toxicology [MMGT], Respiratory medicine [MJL], Immunology [MJCM]
