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Assisted Reproduction Techniques
Challenges and Management Options
Khaldoun Sharif (Edited by), Arri Coomarasamy (Edited by)
9781119622109, Wiley
Hardback, published 1 July 2021
816 pages
25.7 x 18 x 5.1 cm, 1.724 kg
Assisted reproduction techniques have led to the birth of 8 million babies worldwide Assisted reproduction techniques (ART), in particular in-vitro fertilization and intra-cytoplasmic sperm injection, are the most advanced forms of infertility treatment. They involve numerous counseling, medical, surgical and laboratory-based steps. At each step various problems and complications could be encountered that challenge even the most experienced ART practitioners. Moreover, patients with complex medical disorders may require ART, presenting further challenges. Assisted Reproduction Techniques will stimulate resourceful thinking in the ART practitioner when faced with these challenges. It outlines various management options, the reasoning behind them, and the evidence on which they are based to enable the practitioner to choose the most suitable solution for the needs of each patient. Written by 171 internationally renowned experts, Assisted Reproduction Techniques follows the patient's journey throughout the whole ART process, with chapters on: Each of the 116 concise chapters includes clinical cases, background, evidence-based practical management options, preventive measures, key-point summaries of the important details and answers to questions patients ask. Assisted Reproduction Techniques first edition has established its place as a "must read" for ART trainees and practitioners alike, and in this second edition all chapters have been updated, with the addition of new ones addressing training issues, organizational and business skills, and social media use in ART.
Contributors xiii Preface to the second edition xxviii Preface to the first edition xxix How to use this book xxx Abbreviations xxxi Section 1: Counseling and preparation 1 1 Risk of cancer from ovarian stimulation 3 2 Risk of early menopause following IVF treatment 9 3 The HIV-positive female 12 4 The HIV-positive male 19 5 The hepatitis B or C carrier patient 26 6 The patient with cystic fibrosis 32 7 The patient on medication 37 8 The patient with thrombophilia 48 9 The patient with autoimmune disorders 56 10 The patient with malignant disease: fertility preservation 61 11 The patient with heart disease 69 12 The patient with diabetes 75 13 The patient with thyroid disease 81 14 The patient with hyperprolactinemia 89 15 The patient with polycystic ovaries 96 16 The renal transplant patient 103 17 The patient with previous pelvic irradiation 110 18 Female fertility after chemotherapy 116 19 The patient with abnormal cervical cytology 123 20 The patient with previous borderline ovarian tumor 127 21 The patient with an endometrioma 132 22 The patient with cervical stenosis 137 23 Vaccination and ART 142 24 The patient with hydrosalpinx 147 25 The patient with hydrosalpinx and contraindication to laparoscopy 153 26 The patient with reduced ovarian reserve 159 27 The patient with congenital uterine anomalies 166 28 The patient with congenital cervico-vaginal anomalies 171 29 The patient with uterine fibroids 176 30 The patient with adenomyosis 182 31 The patient with previous Essure® sterilization 187 32 The patient with previous endometrial ablation 192 33 The couple with recurrent implantation failure 200 34 The patient with previous uterine artery embolization 207 35 The patient with endometrial polyp 212 36 The obese female patient 217 37 The patient with Asherman syndrome 223 38 The older patient 228 39 Requests for mild or natural cycle IVF treatment 234 40 The patient with psychosexual problems 239 41 The patient needing third-party reproduction 246 42 Social oocyte freezing 252 43 The male and female patients following bariatric surgery 258 44 Endometrial receptivity testing 265 Section 2: Pituitary suppression and ovarian stimulation phase 271 45 Poor response during ovarian stimulation 273 46 Ovarian stimulation for IVF in a patient at high risk of ovarian hyperstimulation syndrome 279 47 Unable to achieve pituitary down-regulation 284 48 The patient discovered pregnant during pituitary down-regulation 291 49 Ovarian cysts following pituitary down-regulation 296 50 Missed IVF medications 302 51 The ART patient with a history of estrogen-receptor Murat Sönmezer and Volkan Turan Section 3: Oocyte retrieval 323 53 General anesthesia or sedation for oocyte retrieval? 325 54 Delayed oocyte retrieval 331 55 Empty follicle syndrome 337 56 Bleeding following oocyte retrieval 344 57 To flush or not to flush follicles at oocyte retrieval 351 58 Inaccessible ovaries at oocyte retrieval 358 59 Endometriotic cysts at oocyte retrieval 363 60 Inadvertent injury during oocyte retrieval 369 61 Dealing with equipment failure during oocyte retrieval 377 Section 4: Embryo transfer 381 62 How many embryos to transfer? 383 63 Poor endometrial development in ART 390 64 Endometrial cavity fluid identified during IVF treatment 400 65 Difficult embryo transfer 404 66 Excess cervical mucus and retained embryos at embryo transfer 413 67 Life after embryo transfer 419 Section 5: The luteal phase 427 68 Vaginal bleeding in the luteal phase after IVF 429 69 Pelvic infection after IVF 435 70 The patient presenting with ovarian hyperstimulation syndrome 440 71 Adnexal torsion after IVF 447 72 Exposure to infection in the luteal phase of IVF 453 Section 6: The ART laboratory 465 73 Total failure of fertilization after conventional IVF – rescue ICSI 467 74 Couples not wishing to create surplus embryos in IVF 473 75 Routine preimplantation genetic testing for aneuploidy 478 76 Choosing an embryo for transfer 484 77 Globozoospermia 492 78 Total failure of fertilization after ICSI 498 79 Refreezing of embryos 503 80 Infection in embryo culture medium 509 81 ICSI or IVF for nonmale-factor infertility? 515 82 Cryostorage failure in ART 522 83 The ART program during a disaster 527 84 Using the wrong sperm or embryos in IVF 533 Section 7: The male patient 539 85 Unexpected inability to produce a semen sample on the day of oocyte retrieval 541 86 The azoospermic patient 545 87 ART in men with Klinefelter syndrome 553 88 ART in men with 100% immotile sperm 559 89 Request for posthumous fatherhood with perimortem surgical sperm retrieval 565 90 Retrograde ejaculation and anejaculation 575 91 Sperm retrieval in cancerous testes 580 92 Leukocytospermia and ART 584 93 The infertile male patient with a genetic cause 589 94 Y chromosome microdeletions and ART 598 95 DNA fragmentation, antioxidants and ART 606 Section 8: The ART pregnancy 613 96 Unexpected number or sex of babies after IVF 615 97 Suspected ectopic pregnancy after IVF 620 98 Cervical ectopic pregnancy after IVF 626 99 Heterotopic pregnancy after IVF 632 100 Multifetal pregnancy reduction after IVF 638 101 Multiple pregnancy after IVF: how to reduce preterm delivery 644 102 Hyperreactio luteinalis after IVF 650 103 Lactation by a commissioning mother in surrogacy 654 104 Children of ART 658 Section 9: General and organizational issues 665 105 Managing physical symptoms during IVF 667 106 IVF when the prognosis is very poor or futile 673 107 Dealing with the emotional distress following failed IVF 678 108 Couple splitting while embryos are in storage 684 109 Unexpected drop in the IVF clinic pregnancy rate 690 110 Natural fertility after IVF 696 111 Training in ART 699 112 Keeping up to date in ART practice 706 113 Cross-border reproductive care 714 114 Satellite and transport ART treatment 720 115 Social media use in ART 725 116 Managing an ART unit as a profitable business 733 Index 739
Yadava Jeve
Sesh Kamal Sunkara
Mark V. Sauer and Shelley Dolitsky
Mark V. Sauer and Shelley Dolitsky
Justin Chu
Tarek El‐Toukhy
Pedro Melo and Arri Coomarasamy
Yorain Sri Ranjan and Ying C. Cheong
Giulia Mariani and José Bellver
Arri Coomarasamy and Manal Elgendy
Anna S. Herrey and Catherine Nelson-Piercy
Mohammed A. Khan, Neelam Potdar, and Justin C. Konje
Shiao-yng Chan
John Ayuk
Adam H. Balen
Justin Chu and Lynne Robinson
Vishvanath C. Karande
Nivedita Reddy
Martyn Underwood and William Rhys Parry-Smith
Arri Coomarasamy, Kavita Singh, and Jennifer Tamblyn
Spyros Chouliaras and Luciano G. Nardo
Khaldoun Sharif
Arri Coomarasamy and Rima Dhillon-Smith
Annika Strandell
Basim Abu-Rafea
Scott M. Nelson
Rima Dhillon-Smith and Pallavi Latthe
Rima Dhillon-Smith and Pallavi Latthe
Kugajeevan Vigneswaran and Haitham Hamoda
Andreas Athanasakis and Arri Coomarasamy
T. Justin Clark
T. Justin Clark
Lukasz Polanski and Yakoub Khalaf
Kugajeevan Vigneswaran and Haitham Hamoda
Arri Coomarasamy and Laurentiu Craciunas
Mostafa Metwally and Bolarinde Ola
Alessandro Conforti, Giuseppe Iorio, and Carlo Alviggi
Giselle Crawford and William Ledger
Brad B. Swelstad and Suheil J. Muasher
Penny Goold and Elizabeth Howland
Imad Aboujaoude and Teddy Tadros
Valerie L. Peddie and Smriti Ray Chaudhuri Bhatta
Zaher Merhi and Ali Ahmed Bazzi
Laurentiu Craciunas and Arri Coomarasamy
Pedro Melo, Lynne Robinson, and Arri Coomarasamy
Khaldoun Sharif and Ahmed G. Serour
K. Jayaprakasan and Nicholas Raine-Fenning
Mohammed Khairy Mahmoud and Arri Coomarasamy
Alison Taylor
Pedro Melo, Lynne Robinson, and Arri Coomarasamy
positive cancer 309
52 The patient over-responding to controlled ovarian stimulation during IVF 315
Khaldoun Sharif
Claire Scanlon and David Green
Khaldoun Sharif
Aboubakr Mohamed Elnashar
Annika K. Ludwig and Barbara Sonntag
Anne E. Martini and Micah J. Hill
Aboubakr Mohamed Elnashar
Graciela Kohls Ilgner and Juan Antonio García-Velasco
Khaldoun Sharif
Isla Robertson and Ying C. Cheong
Ellen Armstrong and Arri Coomarasamy
Jyotsna Pundir and Arri Coomarasamy
Arri Coomarasamy and Yealin Chung
Khaldoun Sharif
Hassan N. Sallam, Ahmed F. Galal, and Fady S. Moeity
Kelton Tremellen
Carol Coughlan and Bolarinde Ola
Muhammad Faisal Aslam and Ali Ahmad Bazzi
Khaldoun Sharif and Dania Al‐Ramahi
Jenna Turocy and Beth W. Rackow
Pedro Melo and Arri Coomarasamy
A. Albert Yuzpe
Hossam Mohamed
Lukasz Polanski and Yakoub Khalaf
Peter Kovacs and Szabolcs Matyas
Odai A. M. Alqawasmeh and Christopher L. R. Barratt
Kaoru Yanagida
Jerome H. Check and Donna Summers
Alison Campbell and Louise Best
Samuel Dobson and Bolarinde Ola
Christopher P. Moutos, Angela H. Liu, and John Y. Phelps
Richard P. Dickey and Carla Ball White
Khaldoun Sharif and Majd M. Ezal‐Deen
Khaldoun Sharif, Majd M. Ezal‐Deen, and Gyath Karadsheh
Khaldoun Sharif and Ali Al-Rawahneh
Medhat Amer and Emad Fakhry
Jose Vázquez Núñez, Juan José Artazkoz Marques de Oliveira, Patricia Hernández Delgado, Ayrton Artazkoz Marques de Oliveira, and Neuda Marques de Oliveira
Mahmoud Mima, Samuel J. Ohlander, Rodrigo L. Pagani, Heather E. Ross, and Lawrence S. Ross
Hussain M. Alnajjar and Asif Muneer
Wael Almajed, Saad Aldousari, and Armand Zini
Giuseppe Ricci
Marlon P. Martinez and Ashok Agarwal
Sherman J. Silber and Sierra Goldsmith
Sarah J. Martins da Silva
Majd M. Ezal-Deen, Mohamad Bani-Domi, and Omar Sharif
Vishvanath C. Karande, Liselotte Mettler,, and Ibrahim Alkatout
Usha Verma and Sabrina Pastor-Carvajal
Abdel‐Maguid Ramzy
Omar Taso and Maher Maaita
Shawqi Saleh and Maysa Khadra
Muataz Al-Ramahi and Omar Sharif
Pavithra Rao and Frank P. Biervliet
Defne Saatci and Alastair G. Sutcliffe
Chiara Achilli and Jyotsna Pundir
Khaldoun Sharif
Sarah R. Holley, Lauri A. Pasch, and Alice D. Domar
Masoud Afnan
Bulent Urman and Kayhan Yakin
Frank Nawroth and Annika K. Ludwig
Ryan J. Heitmann
Bassel H. Al-Wattar and Khalid S. Khan
Mahmoud Salama, Lynn M. Westphal, Marcia C. Inhorn, and Pasquale Patrizio
M. F. González Echeverría and J. A. Blaquier
Natalie M. Crawford, Roohi Jeelani, Lora K. Shahine, and Kenan Omurtag
Michael H. Fakih, Ahmad Fakih, and Amanda Fakih
Subject Areas: Clinical & internal medicine [MJ]
