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Applications of Toxicogenomics in Safety Evaluation and Risk Assessment
Darrell R. Boverhof (Edited by), DR Boverhof (Author), B. Bhaskar Gollapudi (Edited by)
9780470449820, Wiley
Hardback, published 15 July 2011
396 pages
23.4 x 15.5 x 2.5 cm, 0.748 kg
This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process – including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm.
PREFACE ix CONTRIBUTORS xi 1 TOXICOLOGY, "OMICS" TECHNOLOGIES, AND TOXICOGENOMICS: A PRIMER 1 2 INTRODUCTION TO HUMAN HEALTH RISK ASSESSMENT 13 3 PRACTICAL CONSIDERATIONS FOR THE APPLICATION OF TOXICOGENOMICS TO RISK ASSESSMENT: EARLY EXPERIENCE, CURRENT DRIVERS, AND A PATH FORWARD 41 4 APPROACHES AND PRACTICAL CONSIDERATIONS FOR THE ANALYSIS OF TOXICOGENOMICS DATA 65 5 GENOMICS IN IDENTIFYING MUTAGENIC MODE OF ACTION IN CARCINOGENESIS 81 6 APPLICATION OF GENOMICS FOR PREDICTING AND UNDERSTANDING THE MODE OF ACTION FOR NONGENOTOXIC CARCINOGENS 99 7 GENOMICS IN CHARACTERIZING ENDOCRINE TOXICITY 117 8 STUDYING ORGAN-SPECIFIC TOXICITY USING GENE-EXPRESSION PROFILING 147 9 TOXICOGENOMIC STUDIES IN HUMAN POPULATIONS 177 10 TOXICOGENOMICS APPLIED TO ECOLOGICAL RISK ASSESSMENT 207 11 ANALYSIS OF TRANSCRIPTOMIC DOSE–RESPONSE DATA FOR TOXICOLOGY AND RISK ASSESSMENT 237 12 TOXICOGENOMICS AS A TOOL FOR VALIDATING ANIMAL TO HUMAN EXTRAPOLATIONS IN CHEMICAL RISK ASSESSMENT: CONCEPTS, APPLICATIONS, AND CHALLENGES 251 13 TOXICOGENOMICS AND ANIMAL ALTERNATIVES 267 14 TOXICOGENOMICS AND THE REGULATORY FRAMEWORK 293 15 STANDARDIZATION OF GENE-EXPRESSION INFORMATION FOR THE SAFETY EVALUATION: ACTIVITIES IN JAPAN 323 16 APPLYING TRANSCRIPTIONAL PROFILING IN DRUG SAFETY EVALUATION 331 17 REFRAMING THE RISK ASSESSMENT PARADIGM: TOWARD A SYSTEMS BIOLOGY APPROACH 349 INDEX 357
Darrell R. Boverhof and B. Bhaskar Gollapudi
Irene Baskerville-Abraham, Alison Willis, Bernard Gadagbui, and Lynne T. Haber
Darrell R. Boverhof, David R. Geter, B. Bhaskar Gollapudi, and Heli Hollnagel
Zhenqiang Su, Hong Fang, Weida Tong, Huixiao Hong, Roger Perkins, and Leming Shi
Jiri Aubrecht and Ebru Caba
Mark R. Fielden
Jorge M. Naciff and George P. Daston
M. Ann Mongan and Hisham K. Hamadeh
Cliona M. McHale, Luoping Zhang, Alan E. Hubbard, and Martyn T. Smith
Daniel L. Villeneuve, Dalma Martinovi´c, and Gerald T. Ankley
Russell S. Thomas, Longlong Yang, Harvey J. Clewell, and Melvin E. Andersen
Alan Dombkowski and J. Craig Rowlands
Anne S. Kienhuis, Joost H. M. van Delft, and Jos C. S. Kleinjans
Kathryn Gallagher, Federico M. Goodsaid, David J. Dix, Susan Y. Euling, Melissa Kramer, Nancy E. McCarroll, Julian R. Preston, Philip G. Sayre, Banalata Sen, Douglas C. Wolf, and William H. Benson
Ken-ichi Aisaki and Jun Kanno
Lois D. Lehman-McKeeman and William R. Foster
Sarah N. Campion and Kim Boekelheide
Subject Areas: Chemistry [PN]
