Antimicrobial Peptides in Gastrointestinal Diseases

Presents information on the physiological functions and pharmacological actions of antimicrobial peptides in gastrointestinal diseases

Chi Hin Cho (Edited by)

9780128143193

Paperback, published 8 June 2018

186 pages
22.9 x 15.1 x 1.3 cm, 0.31 kg

Antimicrobial peptides (AMPs), including cathelicidins and defensins are host defence peptides that carry out multiple roles in the gastrointestinal (GI) tract. Antimicrobial Peptides in Gastrointestinal Diseases presents knowledge about the physiological functions and pharmacological actions of AMPs in inflammation, cancer, and further infection of the GI tract. The book provides coverage from the basic research to clinical application for GI diseases. Current research and development of AMPs is presented, opening the way for further work on these peptides, not only in the context of GI diseases, but also for similar pathologies in other organs. AMPs are key to the regulation of human microbiome and second line defence in the GI mucosa, prevent colonization of pathogens and modulation of innate response to invading pathogens, and modify immunological reactions during inflammatory processes and oncogenic development in the GI mucosa. More importantly, AMPs possess diversified anti-microbial actions against various infectious diseases in the GI tract. With these physiological functions and pharmacological actions, AMPs have significant potential as therapeutic agents for the treatment of inflammation, cancer and further infection in the GI tract.

1. Introduction of AMPs in the biological system including their norm and pathology 2. Regulation of AMPs expression in the digestive tract 3. The roles of antimicrobial peptides in the regulation of gastrointestinal microbiota and innate immunity 4. Inflammatory Bowel Disease Center, Division of Digestive Diseases 5. Antimicrobial peptides in the host-microbiota homeostasis 6. Antimicrobial peptides as potential therapy for gastrointestinal cancers: Opportunities and Challenges 7. Cathelicidin in gastrointestinal disorders 8. Modulation of immune functions by host defense peptides in the pathogenesis of colitis 9. AMPs and mechanisms of anti-microbial action

Subject Areas: Life sciences: general issues [PSA], Immunology [MJCM]