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Antibody Fc
Linking Adaptive and Innate Immunity
The first book to synthesize the vast literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response into a single source of accessible reviews
Margaret Ackerman (Edited by), Falk Nimmerjahn (Edited by)
9780123948021, Elsevier Science
Hardback, published 26 September 2013
358 pages
23.4 x 19 x 2.5 cm, 0.91 kg
"…highly recommended reading for all students of immunology and scientists involved in the research and development of therapeutic antibodies and vaccines because of its comprehensive coverage of relevant topics…also recommended as an excellent resource for academic, government and company libraries." --mAbs, May/June 2014 "Antibody Fc: Linking Adaptive and Innate Immunity is highly recommended reading for all students of immunology and scientists involved in the research and development of therapeutic antibodies and vaccines because of its comprehensive coverage of relevant topics…The book is also recommended as an excellent resource for academic, government and company libraries." --mAbs, March 21, 2014 "Ackerman and Nimmerjahn offer this volume on the immunological functions of the Fc antibody region. The first two parts discuss effector mechanisms and their mediating cells including antibody-dependent cytotoxicity, the complement system, phagocytosis, natural killer and B cells. Parts III-IV cover general properties of Fc immune receptors, receptor variation amongst species, and the structural variations and glycoside modifications of the Fc domain." --ProtoView.com, February 2014
Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology. Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells.
Part 1: Effector Mechanisms Ch 1: Antibody Dependent Cellular Cytotoxicity Ch 2: Antibody-Dependent Cellular Phagocytosis and its Impact on Pathogen Control Ch 3: Interactions between the Complement System and Fc? Receptors Part 2: Effector Cells Ch 4: Natural Killer Cells Ch 5: Phagocytes and Immunoglobulins Ch 6: B Cells Part 3: FcR Ch 7: Structural Recognition of Immunoglobulins by Fcg Receptors Ch 8: Fc?Rs Across Species Part 4: Variability of the Fc Domain Ch 9: Human IgG Subclasses Ch 10: Antibody Glycosylation Part 5: Genetic Associations Ch 11: Activating and Inhibitory Fc?Rs in Autoimmune Disorders Ch 12: Fcg Receptor Polymorphisms and Susceptibility to Infection Ch 13: Role of IgG Fc Receptors in Monoclonal Antibody Therapy of Cancer Part 6: Evolving areas Ch 14: Interactions Among Monoclonal Antibody Mechanisms of Action Ch 15: Fc Receptor-Dependent Immunity Ch 16: Fc? Receptors as Therapeutic Targets Ch 17: Fc Protein Engineering Ch 18: Bacterial Modulation of Fc Effector Functions Ch 19: Pathogenic Exploitation of Fc Activity Ch 20: Mechanisms of Immunoglobulin-Mediated Mucus Entrapment of Pathogens at Various Mucosal Surfaces
Subject Areas: Immunology [MJCM], Infectious & contagious diseases [MJCJ]
