Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging

Describes the hallmarks of aging and how they can be applied in anti-aging strategies for drug discovery

Sandeep Kumar Singh (Edited by), Chih Li Lin (Edited by), Shailendra Kumar Mishra (Edited by)

9780323902359, Elsevier Science

Paperback / softback, published 29 July 2022

410 pages, 60 illustrations (10 in full color)
23.5 x 19 x 2.6 cm, 0.81 kg

Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging is a comprehensive and timely book on all aspects of anti-aging strategies. The book provides comprehensive, foundational knowledge on the mechanisms of aging and current anti-aging strategies and approaches developed. Aging research has experienced an unprecedented advance over recent years with the discovery that the rate of aging is determined, at least to some extent, mainly by our genetics and modulated by environmental factors. The hallmarks of aging describe the molecular and cellular processes that govern biological aging and their variation in individuals.

1. The aging: introduction, theories, principles and future prospective Shabnam Shabir, Mahendra Pratap Singh 2. Brief description of aging in different levels as cellular, tissues, and organs Anuradha Venkatakrishnan Chimata, Prajakta Deshpande, Amit Singh 3. Brief about hallmarks of aging Josephine Esposto and Vyshnavy Balendra 4. Overview of various anti-aging strategies Dhiraj Kumar and Faiyaz Ahmad 5. Elimination of damaged cells-dependent anti-aging strategy Rayees Ahmad Naik, Vinodinee Dubey, Roshni Rajpoot, Debabrata Dash, Nidhi Gupta and Raj Kumar Koiri 6. Telomerase reactivation for anti-aging TS Gopenath, Shreya Shreshtha and Kanthesh M. Basalingapa 7. Epigenetic drugs based on anti-aging approach Tarun Minocha, Namrata Dwivedi, Chetan Panda, Anamika Misra, Barsha Baisakhi Nayak, Sanjeev Kumar Yadav, Hareram Birla and Sandeep K. Singh 8. Activation of chaperons and proteolytic system: emerging methods for anti-aging drug development Neha Gogia, Victor Olmos, Fatema Haidery, Kimberly Luttik, Leon Tejwani, Janghoo Lim 9. Dietary restriction and mTOR and IIS inhibition: the potential to anti-aging drug approach Sing-Hua Tsou 10. Anti-Aging Drugs, Candidates, and Food Supplements- The journey so far Yodhaanjali JR, Rithwick Surya, Sumukha KC, Harini G, Gouri Deshpande, Chandan S,Raghu Ram Achar 11. Role of AMPK and Sirtuins as anti-aging proteins Manjula Ramu, Sonali Vishal and Neha Gogia 12. Mitophagy and Mitohormetics: promising anti- aging strategy Chih Li Lin 13. Clearance of senescent cells: potent anti-aging approach Jacques Ferreira and Alex Deamer 14. Stem cell-based therapy as antiaging prospective Sumaira Yusuf, Mahendra P. Singh 15. Anti-inflammatory therapy as a game changer towards anti-aging Dr. Naveen Shivavedi, Anshul Shakya, Bedanta Bhattacharjee and Bhargab Deka 16. Invertebrate model organisms for aging research Arvind Kumar Shukla, Andrew Scott and Edward Giniger

Subject Areas: Geriatric medicine [MJX], Diabetes [MJGD], Endocrinology [MJG]