• Annual Reports in Medicinal Chemistry (Paperback / softback) 9780123809025
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Annual Reports in Medicinal Chemistry

John E. Macor (Series edited by)

9780123809025, Elsevier Science

Paperback / softback, published 25 November 2010

648 pages
22.9 x 15.1 x 4 cm, 0.86 kg

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.

Section I: Central Nervous System Diseases – ROBICHAUD

  1. Voltage-Gated Calcium Channel Antagonists for the Central Nervous System

    2. James C. Barrow and Joseph L. Duffy

  2. Recent Developments in Glycine Transporter-1 Inhibitors

    3. Christopher L. Cioffi, Shuang Liu and Mark A.Wolf

  3. Modulators of Transient Receptor Potential Ion Channels

    4. Rajagopal Bakthavatchalam and S. David Kimball

  4. Defining Neuropharmacokinetic Parameters in CNS Drug Discovery to Determine Cross-species Pharmacologic Exposure-Response Relationships

    5. Christopher L. Shaffer

    Section II: Cardiovascular and Metabolic Diseases - STAMFORD

  5. High Affinity Niacin Receptor GPR109A Agonists

    6. Hong C. Shen and Steven L. Colletti

  6. Recent Advances in Acetyl CoA Carboxylase (ACC) Inhibitors

    7. Matthew P. Bourbeau, John G. Allen, and Wei Gu

  7. Enzymatic Targets in the Triglyceride Synthesis Pathway

    8. Dmitry O. Koltun and Jeff Zablocki

  8. Inhibitors of HIF Prolyl Hydroxylases

    9. Michael H. Rabinowitz, Terrance D. Barrett, Mark D. Rosen, Hariharan Venkatesan

    Section III: Inflammation / Pulmonary / GI - BARRISH/Weinstein

  9. Opioid Receptor Antagonists for Gastrointestinal Dysfunction

    10. R. William Hipkin and Roland E. Dolle

  10. CFTR Modulators for the Treatment of Cystic Fibrosis

    11. Sabine Hadida, Frederick Van Goor and Peter D. J. Grootenhuis

  11. Targeting B-cells in inflammatory disease

    12. Kevin S. Currie

  12. Modulators of Toll-Like Receptor (TLR) Signaling

    13. Mark Spyvee, Lynn Hawkins, and Sally Ishizaka

    Section IV: Oncology - McAlpine

  13. Janus Kinase 2 (JAK2) inhibitors for the treatment of myeloproliferative neoplasm (MPN)

    14. Ashok V. Purandare, Matthew V. Lorenzi and Louis J. Lombardo

  14. Development of poly(ADP-ribose)polymerase (PARP) inhibitors in oncology

    15. Philip Jones

  15. Epigenetic Targets and Cancer Drug Discovery

    16. Patrick M. Woster, Ph.D

    Section V: Infectious Diseases - Primeau

  16. HIV-1 Integrase Strand Transfer Inhibitors

    17. Brian A. Johns

  17. Recent Advances in Drug Discovery for Neglected Tropical Diseases Caused by Infective Kinetoplastid Parasites

    18. Robert T. Jacobs and Charles Ding

  18. Recent Advances in the Inhibition of Bacterial Fatty Acid Biosynthesis

    19. Vincent Gerusz

    Section VI: Topics in Biology - LOWE

  19. Back to the Plaque: Emerging Studies That Re-Focus Attention on the Neuritic Plaque in Alzheimer’s Disease

    20. Dr. Robert B. Nelson

  20. Targeting Methyl Lysine

    21. Stephen V. Frye, Tom Heightman and Jian Jin

  21. Chemical Proteomic Technologies for Drug Target Identification

    22. Kieran F. Geoghegan and Douglas S. Johnson

  22. NIH Translational Programs for Assisting Pre-Clinical Drug Discovery and Development

    23. Raj N. Misra

    Section VII: Topics in Drug Design and Discovery - DESAI

  23. Role of Physicochemical Properties and Lipophilic Ligand Efficiency (LipE or LLE) in addressing Drug Safety Risks

    24. Martin P. Edwards and David A. Price

  24. Reducing the Risk of Drug Attrition Associated with Physicochemical Properties

    25. Paul D. Leeson and James R. Empfield

  25. Compound Collection Enhancement and Paradigms for High Throughput Screening - an Update

    26. Stevan W Djuric, Irini Akritopoulou-Zanze, Philip B Cox and Scott Galasinski

  26. The Role of Fluorine in the Discovery and Optimization of CNS Agents: Modulation of Drug-Like Properties

    27. Kevin J. Hodgetts, Kerry J. Combs, Amy M. Elder and Geraldine C. Harriman

  27. Patents in Drug Discovery: Case Studies, Examples, and Simple Steps Medicinal Chemists Can Take to Protect Hard-Won Intellectual Property

    28. Charles J. Andres, Jr. and Richard L. Treanor

    Section VIII: Trends and Perspectives

  28. To Market, To Market – 2009

Shridhar Hegde and Michelle Schmidt

Subject Areas: Organic chemistry [PNN], Pharmacology [MMG]
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