Angiogenesis: In Vivo Systems, Part A

Angiogenesis has been identified as a “common denominator” in society’s most serious diseases and more than $4 billion has been invested in the research and development of angiogenesis-based medicines, making it one of the most heavily funded areas of medical research in history.

David A. Cheresh (Edited by)

9780123743138, Elsevier Science

Hardback, published 10 November 2008

400 pages
22.9 x 15.1 x 2.6 cm, 0.77 kg

Angiogenesis is the growth of new blood vessels and is an important natural process in the body. A healthy body maintains a perfect balance of angiogenesis modulators. In many serious disease states, however, the body loses control over angiogenesis. Diseases that are angiogenesis-dependent result when blood vessels either grow excessively or insufficiently. Understanding how angiogenesis "works" and how to control it, will have massive implications on the management, treatments, and ultimately the prevention of many common (and not so common) diseases. Angiogenesis cuts across virtually every discipline. The Angiogenesis Foundation identified angiogenesis as a "common denominator" in our most serious diseases. Excessive angiogenesis occurs in diseases such as cancer, diabetic blindness, age-related macular degeneration, rheumatoid arthritis, psoriasis, and many other conditions. Insufficient angiogenesis occurs in diseases such as coronary artery disease, stroke, and delayed wound healing.

Isolation of natural angiogenesis inhibitors and their function
Chick CAM models
Ultrastructure analysis of blood vessels
Zebrafish models
Lymphangiogenesis models and applications
Models of vascular permeability
Tumor models to study angiogenesis inhibitors
Studying hemangiomas and vascular malformations
Ocular models of angiogenesis
Models of ischemia and ischemia/reperfusion
Vascular neural patterns
Identification of important genes in vascular development
Imaging of tumor blood vessels
Imaging of blood vessels (in situ terminal models)
In vivo assays to screen anti-angiogenic agents
Blood vessel normalization
Patterning (neurons, ECM, EC) during angiogenesis, vascular regression, inhibitors

Subject Areas: Cellular biology [cytology PSF], Molecular biology [PSD], Biochemistry [PSB], Life sciences: general issues [PSA], Biophysics [PHVN], Pharmacology [MMG], Cardiovascular medicine [MJD], Physiology [MFG]