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Anaerobiosis and Stemness
An Evolutionary Paradigm for Therapeutic Applications
This book provides a complete and first-to-market review and analysis of the relevant literature in the field of hypoxia, hypoxic regulation, and stem cell maintenance to assist in the progression toward clinical application.
Zoran Ivanovic (Author), Marija Vlaski-Lafarge (Author)
9780128005408
Hardback, published 1 December 2015
326 pages
22.9 x 15.1 x 2.4 cm, 0.72 kg
"...provides the key for understanding and predicting stem cell behavior in vivo and ex vivo, which is of paramount importance for the cell engineering and anti-cancer strategies." --Serbian Archives of Medicine "The “evolutionary stem cell paradigm?of Z. Ivanovic and M. Vlaški provides the key for understanding and predicting stem cell behavior in vivo and ex vivo, which is of paramount importance for the cell engineering and anti-cancer strategies. The concept of anaerobiosis and stemness presented in this unique book implies the epigenetic missing link in stem cells behavior. The evolutionary paradigm described, although partly hypothetical, is important for understanding developmental biology." --Professor Pavle Milenkovic, MD, PhD, President of the Academy of Medical Sciences, Serbian Medical Society
Anaerobiosis and Stemness: An evolutionary paradigm provides a context for understanding the many complexities and evolutionary features of stem cells and the clinical implications of anaerobiosis stem cells. Combining theoretical and experimental knowledge, the authors provide a broad understanding of how the absence or low concentration of oxygen can play an influential role in the maintenance and self-renewal of stem cells and stem cell differentiation. This understanding has clinical implications for the fields of regenerative medicine, cancer biology and transplantation, as well as cell engineering and cell therapy. Anaerobiosis and Stemness is an important resource for stem cell and developmental biologists alike, as well as oncologists, cancer biologists, and researchers using stem cells for regeneration.
TABLE OF CONTENTS:PREFACESPECIAL REMARKS1) What entity could be called a “stem cell??2) In situ “normoxia? vs. “hypoxia?Part I:ANAEROBIOSIS AND STEM CELL ENTITY1) The “hypoxic? stem cell niche2) Low O2 concentrations and the maintenances of stem cells ex vivo 3) Quiescence/proliferation issue and stem cell niche4) Metabolic peculiarities of the stem cell entity: energetic metabolism and oxidative status5) “Hypoxic? signaling, metabolic type, quiescence, self-renewal and differentiation Part II:ANAEROBIC-TO-AEROBIC EUKARYOTE EVOLUTION – A PARADIGM FOR STEM CELL SELF-RENEWAL, COMMITMENT AND DIFFERENTIATION?1) Evolution of eukaryotes with respect to the appearance and rise of oxygen in the atmosphere: anaerobiosis, facultative aerobiosis and aerobiosis 2) Evolution of mitochondria in eukaryotes and mitochondria “maturing? from stem cells to committed progenitors and mature cells3) Evolutionary origins of stemness: relationship between self-renewal and ancestral eukaryote biology; conservation of self-renewal principle in parallel with the adaptation to O24) Metabolic and genetic features of ancestral eukaryotes vs. metabolism and “master pluripotency genes? of stem cells5) Some other features concerning the analogy "stem cells - primitive eukaryotes": ABC transporters’ anaerobiosis/stemness link6) Harnessing anaerobic nature of stem cells for the use in regenerative medicine 7) Cancer stem cell case and evolutionary paradigm
Subject Areas: Cellular biology [cytology PSF], Molecular biology [PSD], Developmental biology [PSC], Biomedical engineering [MQW]
