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An Introduction to Pain and its relation to Nervous System Disorders
Anna A. Battaglia (Edited by)
9781118455975, Wiley
Paperback / softback, published 6 May 2016
448 pages
24.6 x 19.1 x 2 cm, 0.953 kg
Introduction to Pain and its relation to Nervous System Disorders provides an accessible overview of the latest developments in the science underpinning pain research, including, but not limited to, the physiological, pathological and psychological aspects. This unique book fills a gap in current literature by focussing on the intricate relationship between pain and human nervous system disorders such as Autism, Alzheimer Disease, Parkinson’s Disease, Depression and Multiple Sclerosis. This fully illustrated, colour handbook will help non-experts, including advanced undergraduate and new postgraduate students, become familiar with the current, wide-ranging areas of research that cover every aspect of the field from chronic and inflammatory pain to neuropathic pain and biopsychosocial models of pain, functional imaging and genetics. Contributions from leading experts in neuroscience and psychiatry provide both factual information and critical points of view on their approach and the theoretical framework behind their choices. An appreciation of the strengths and weaknesses of brain imaging technology applied to pain research in humans provides the tools required to understand current cutting edge literature on the topic. Chapters covering placebo effects in analgesia and the psychology of pain give a thorough overview of cognitive, psychological and social influences on pain perception. Sections exploring pain in the lifecycle and in relation to nervous system disorders take particular relevance from a clinical point of view. Furthermore, an intellectually stimulating chapter analysing the co-morbidity of pain and depression provides a philosophical angle rarely presented in related handbooks. The references to external research databases and relevant websites aim to prompt readers to become critical and independent thinkers, and motivate them to carry out further reading on these topics. Introduction to Pain and its relation to Nervous System Disorders is essential reading for advanced undergraduate and postgraduate students in neuroscience, medical and biomedical sciences, as well as for clinical and medical healthcare professionals involved in pain management.
List of contributors ix Foreword xiii Acknowledgements xv Notes on authors xvii Introduction 1 Section I: Neurobiology of pain: Recent advances 11 1 Anatomy of pain pathways 13 2 Spinal plasticity of the nociceptive system: The role of central sensitisation in chronic pain states 35 3 Symptoms and pathology in neuropathic pain 89 4 Recent advances in neuroimmune interactions in neuropathic pain: The role of microglia 123 5 Genetics and epigenetics of pain 149 6 The cannabinoid system and its role in nociception 169 7 EphB receptors and persistent pain 201 Section II: Pain in the brain 225 8 Brain imaging in experimental pain 227 9 Placebo effects in pain 249 10 Psychology and pain 267 Section III: Pain in the lifecycle and in nervous system disorders 281 11 Pain in neonates and infants 283 12 How do people with autism spectrum disorders (ASD) experience pain? 295 13 Pain and depression: The janus factor of human suffering 317 14 Pain in multiple sclerosis: From classification to treatment 345 15 Pain perception in dementia 361 16 The role of cognitive impairment in the placebo and nocebo effects 373 17 An overview of pain in Parkinson’s disease 387 Appendix: Interviews with chronic pain patients 409 Index 413
Anna A. Battaglia
Andrew J. Todd
Alban Latrémolière
Matthew Thakur and Stephen B. McMahon
Elizabeth A. Old, Louise S. C. Nicol and Marzia Malcangio
Franziska Denk and Stephen B. McMahon
Massimiliano Beltramo
Isabella Gavazzi
Massieh Moayedi and Tim V. Salomons
Luana Colloca, Adam P. Horin and Damien Finniss
Lance M. McCracken
Fiona Moultrie, Segzi Goksan, Ravi Poorun and Rebeccah Slater
Cecile Rattaz, Amandine Dubois and Amaria Baghdadli
Angela Iannitelli and Paola Tirassa
Claudio Solaro and Michele Messmer Uccelli
Miriam Kunz and Stefan Lautenbacher
Martina Amanzio
Panagiotis Zis, Elisaveta Sokolov and Kallol Ray Chaudhuri
Subject Areas: Biology, life sciences [PS]
