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Aminoglycoside Antibiotics
From Chemical Biology to Drug Discovery
Dev P. Arya (Author)
9780471743026, Wiley
Hardback, published 3 August 2007
336 pages
24.3 x 16.3 x 2.4 cm, 0.621 kg
"This is a 'must-have' text for anyone involved in AGA teaching or research. No better comprehensive treatise exists…" (Journal of Medicinal Chemistry, October 18, 2007) "There is little doubt that this volume will be a tremendous resource for any investigator interested in the biochemistry of aminoglycosides." (Journal of the American Chemical Society, September 26, 2007)
Advances that open new avenues in developing aminoglycoside antibiotics
During the last twenty years, there have been numerous advances in the understanding of the chemistry, biochemistry, and recognition of aminoglycosides. This has led to the development of novel antibiotics and opened up new therapeutic targets for intervention. This is the first book to provide a complete overview of recent advances in the field and explore their tremendous potential for drug discovery and rational drug design. With chapters written by one or more leading experts in their specialty areas, the book addresses the chemistry, biology, and toxicology of aminoglycosides.
Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery is a great resource for academic and industrial researchers in drug design and mechanism studies and for researchers studying antibiotic resistance, antibiotic design and synthesis, and the discovery of novel pharmaceuticals. It is also a valuable reference for graduate students in pharmacy, pharmaceutical science, biophysics, medicinal chemistry, and chemical biology.
Preface vii Contributors ix 1. In the Beginning There Was Streptomycin 1 2. The Biochemistry and Genetics of Aminoglycoside Producers 15 3. Mechanisms of Aminoglycoside Antibiotic Resistance 119 4. Design, Chemical Synthesis, and Antibacterial Activity of Kanamycin and Neomycin Class Aminoglycoside Antibiotics 141 5. NMR Structural Studies of Aminoglycoside: RNA Interaction 181 6. Structural Comparisons Between Prokaryotic and Eukaryotic Ribosomal Decoding a Sites Free and Complexed with Aminoglycosides 209 7. Binding of Antibiotics to the Aminoacyl-tRNA Site of Bacterial Ribosome 225 8. Metalloaminoglycosides: Chemistry and Biological Relevance 235 9. Adverse Effects of Aminoglycoside Therapy 255 10. Targeting HIV-1 RNA with Aminoglycoside Antibiotics and Their Derivatives 267 11. Novel Targets for Aminoglycosides 289 Index 315
Julian Davies
Wolfgang Piepersberg, Khaled M. Aboshanab, Heike Schmidt-Beißner, and Udo F. Wehmeier
Tushar Shakya and Gerard D. Wright
Jinhua Wang and Cheng-Wei Tom Chang
R. Andrew Marshall and Joseph D. Puglisi
Jiro Kondo and Eric Westhof
Dale Kling, Christine Chow, and Shahriar Mobashery
Nikhil Gokhale, Anjali Patwardhan, and J. A. Cowan
Andra E. Talaska and Jochen Schacht
Lev Elson-Schwab and Yitzhak Tor
Dev P. Arya, Nicholas Shaw, and Hongjuan Xi
Subject Areas: Chemistry [PN]
