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Alzheimer's Disease
Life Course Perspectives on Risk Reduction
This reference distills a large body of knowledge about the distribution and causes of Alzheimer’s disease in human populations using a lifecourse approach that explains how the disease is defined and its progression, along with its risk and protective factors
Amy Borenstein (Author), James Mortimer (Author)
9780128045381, Elsevier Science
Hardback, published 11 February 2016
466 pages
22.9 x 15.1 x 2.9 cm, 0.93 kg
"Drs. Borenstein and Mortimer have produced a remarkable text on the topic of the epidemiology of Alzheimer’s disease that is destined to become a classic in the field. These scholars have used methodological rigor to dissect a complicated area of study and have accomplished a tour de force for practitioners and scientists." --Ronald C. Petersen, PhD, MD, Mayo Clinic "In this book, two of the world leaders of dementia epidemiology summarize their knowledge gained over more than four decades. Essential for researchers, clinicians and others interested in the distribution, causes and consequences of Alzheimer’s disease, this book will be a standard reference in dementia epidemiology for many years." --Ingmar Skoog, PhD, MD, University of Gothenburg "An important book and a must for epidemiologists and physicians studying dementia in populations." --Jean François Dartigues, PhD, MD, University of Bordeaux
Alzheimer's Disease: Lifecourse Perspectives on Risk Reduction summarizes the growing body of knowledge on the distribution and causes of Alzheimer’s disease (AD) in human populations, providing the reader with knowledge on how we define the disease and what its risk and protective factors are in the context of a life-course approach. At the conclusion of the book, the reader will understand why Alzheimer’s disease likely begins at conception, then progresses through early-life and adult risk factors that ultimately impact the balance between pathologic insults in the brain and the ability of the brain to modify disease symptoms. In contrast to edited volumes that may have little cohesion, this book focuses on an integrated life-course approach to the epidemiology of dementia, in particular, Alzheimer’s disease.
Prologue: A Primer on Epidemiologic Concepts and MethodsSection 1. Defining a CaseChapter 1. The "First" CaseChapter 2. Clinical Appearance, Progression, and ClassificationChapter 3. Epidemiologic Definition of a CaseChapter 4. Neuropathology of Alzheimer's DiseaseChapter 5. The Threshold Model of DementiaSection 2. Descriptive EpidemiologyChapter 6. The Prevalence of Alzheimer's DiseaseChapter 7. The Incidence of Alzheimer's DiseaseChapter 8. Survival and Mortality in Alzheimer's DiseaseSection 3. Analytic EpidemiologyChapter 9. Introduction to the Analytic Epidemiology of Azheimer's DiseaseChapter 10. Family History, Genetics, and Down Syndrome Chapter 11. Early-Life FactorsChapter 12. Traumatic Brain InjuryChapter 13. Gigarette Smoking and Alcohol ConsumptionChapter 14. Vascular DiseaseChapter 15. DietChapter 16. Physical ActivityChapter 17. Cognitive ActivityChapter 18. Social EngagementChapter 19. Non-Steroidal Anti-Inflammatory Drugs, Hormone Replacement Therapy, and Anticholinergic MedicationsSection 4. Epidemiologic and Biologic MarkersChapter 20. Prodromal Markers of Disease or Causal Risk Factors? Depression, Olfaction, and Subjective Memory ComplaintsChapter 21. Fluid, Imaging, and Cognitive Biomarkers Section 5. Future StepsChapter 22. Risk Assessment and Prevention of Alzheimer's DiseaseChapter 23. Summary and Recommendations
Subject Areas: Physiological & neuro-psychology, biopsychology [JMM], Cognitive science [GTR]
