Alloimmune Disorders of Pregnancy
Anaemia, Thrombocytopenia and Neutropenia in the Fetus and Newborn

Overview of the alloimmune disorders of pregnancy which arise from maternal immunisation to fetal blood cells.

Andrew Hadley (Edited by), Peter Soothill (Edited by)

9780521781206, Cambridge University Press

Hardback, published 6 December 2001

306 pages, 24 b/w illus. 35 tables
25.6 x 18 x 2.2 cm, 0.823 kg

"This book will serve as a useful resource for the many participants in multidisciplinary teams that manage alloimmune disorders in pregnancy. It should serve to enhance communication and coordination among investigators and clinical specialists in each of the contributing fields, thus achieving the editors' goals." The New England Journal of Medicine

Collectively known as the alloimmune cytopenias, hemolytic disease of the fetus and newborn, alloimmune thrombocytopenia and alloimmune neutropenia are all consequences of maternal immunisation to fetal blood cells. The effective prevention, diagnosis and management of these disorders has become a team effort involving haematologists, obstetricians, paediatricians, immunologists, laboratory technicians, midwives and research scientists. This book has been written by experts in their respective fields to bring together the issues of pathogenesis, epidemiology, prevention, diagnosis and clinical management. This comprehensive but accessible account is extensively cross-referenced to emphasise the links between pathogenesis and clinical sequelae, between epidemiology and the rationale for screening programmes, and between diagnosis and therapeutic intervention. This is an authoritative overview suitable for trainees in obstetrics, materno-fetal medicine, transfusion medicine and clinical immunology.

Preface Andrew G. Hadley and Peter Soothill
1. Pathophysiology of the alloimmune cytopenias Andrew G. Hadley and Craig Turner
2. Blood group antibodies in haemolytic disease of the fetus and newborn Geoff Daniels
3. Basis and practice of screening for haemolytic disease of the fetus and newborn Geoff Poole
4. Epidemiology and screening for alloimmune thrombocytopenia Lorna M. Williamson and Michael F. Murphy
5. Principles of antibody-mediated immune suppression and the prevention of maternal Rh(D) alloimmunisation Belinda Kumpel
6. The clinical application of anti-D prophylaxis Stan Urbaniak
7. Fetal genotyping Neil D. Avent
8. Laboratory assays to determine the severity of haemolytic disease of the fetus and newborn Andrew G Hadley
9. Assessing the severity of haemolytic disease of the fetus and newborn: clinical aspects Sherif Abdel-Fattah and Peter Soothill
10. Antenatal therapy for haemolytic disease of the fetus and newborn Kenneth J. Moise and Paul W. Whitecar
11. Neonatal therapy for haemolytic disease of the newborn Glynn Russell and Nic Goulden
12. The diagnosis of alloimmune thrombocytopenia Andrew Hadley
13. The diagnosis of alloimmune neutropenia Geoff Lucas
14. Fetal and neonatal treatment of alloimmune thrombocytopenia Michael Murphy, Rachel Rayment, David Allen and David Roberts
Index.

Subject Areas: Materno-fetal medicine [MJTF], Gynaecology & obstetrics [MJT], Haematology [MJF], Immunology [MJCM]