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Advances in Enzymology and Related Areas of Molecular Biology, Volume 78
Eric J. Toone (Edited by), EJ Toone (Author)
9781118014288, Wiley
Hardback, published 16 December 2011
560 pages
23.6 x 16.3 x 3.6 cm, 0.943 kg
This book covers important advances in enzymology, explaining the behavior of enzymes and how they can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes. Advances in Enzymology focuses on enzymes, the primary catalysts of life processes. The explanation of the behavior of enzymes can be found via studies of their chemical mechanisms and can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes. The transglutaminases, first described in 1957, are a large, widely-distributed family of enzymes canonically responsible for the amidation/transamidation of protein side chains. The extraordinary diversity of names associated with various enzymatic activities now recognized and aggregated as transglutaminase bears witness to the remarkable diversity of biological roles associated with the activity, including myriad human diseases.
Contributors vii Preface ix Structure and Regulation of Type 2 Transglutaminase in Relation to Its Physiological Functions and Pathological Roles 1 Physiopathological Roles of Human Transglutaminase 2 47 Transglutaminase in Epidermis and Neurological Disease or What Makes a Good Cross-Linking Substrate 97 Transglutaminase 2: A New Paradigm for NF-B Involvement in Disease 161 Transglutaminase 2 At the Crossroads between Cell Death and Survival 197 Tissue Transglutaminase and Its Role in Human Cancer Progression 247 Transglutaminase 2 Dysfunctions in the Development of Autoimmune Disorders: Celiac Disease and TG2−/−Mouse 295 Effects and Analysis of Transglutamination on Protein Aggregation and Clearance in Neurodegenerative Diseases 347 Transglutaminase-Mediated Remodeling of the Human Erythrocyte Membrane Skeleton: Relevance for Erythrocyte Diseases with Shortened Cell Lifespan 385 Irreversible Inhibitors of Tissue Transglutaminase 415 Methionine Adenosyltransferase (S-Adenosylmethionine Synthetase) 449 Index 523
Carlo M. Bergamini, Russell J. Collighan, Zhuo Wang, and Martin Griffin
Vittorio Gentile
Guylaine Hoffner, Amandine VanHoutteghem, William Andre, and Philippe Djian
Soo-Youl Kim
Mauro Piacentini, Manuela D’Eletto, Laura Falasca, Maria Grazia Farrace, and Carlo Rodolfo
Bo Li, Richard A. Cerione, and Marc Antonyak
Zsuzsa Szondy, Ilma Korponay-Szabo, Robert Kiraly, and Laszlo Fesus
Zoltan Nemes
Laszlo Lorand, S. N. Prasanna Murthy, Anwar A. Khan, Weihua XUE, Oksana Lockridge, and Athar H. Chishti
Jeffrey W. Keillor, Nicolas Chabot, Isabelle Roy, Amina Mulani, Olivier Leogane, and Christophe Pardin
Marıa A. Pajares and George D. Markham
Subject Areas: Chemistry [PN]
