Advanced Topics in Forensic DNA Typing: Methodology

Comprehensive, in-depth ‘BIBLE’ of forensic DNA research relevant to forensic practitioners and researchers, by the foremost expert in the field

John M. Butler (Author)

9780123745132, Elsevier Science

Hardback, published 27 July 2011

708 pages
23.4 x 19 x 3.7 cm, 1.56 kg

"John Butler has produced a series of books detailing the major issues involved in forensic DNA typing. His latest book on advanced topics in DNA typing provides exceptional coverage of this complex and difficult topic. Through his work at NIST and his many collaborations with forensic analysts, Dr. Butler has kept up to date with all recent advances in the field. In his book he brings remarkable clarity through examples, diagrams, and case notes that is unsurpassed in any other text on the subject." --Bruce McCord, Professor, Department of Chemistry and Biochemistry, Florida International University, Miami, Florida

Intended as a companion to the Fundamentals of Forensic DNA Typing volume published in 2009, Advanced Topics in Forensic DNA Typing: Methodology contains 18 chapters with 4 appendices providing up-to-date coverage of essential topics in this important field and citation to more than 2800 articles and internet resources. The book builds upon the previous two editions of John Butler’s internationally acclaimed Forensic DNA Typing textbook with forensic DNA analysts as its primary audience.  This book provides the most detailed information written to-date on DNA databases, low-level DNA, validation, and numerous other topics including a new chapter on legal aspects of DNA testing to prepare scientists for expert witness testimony. Over half of the content is new compared to previous editions. A forthcoming companion volume will cover interpretation issues.

1. Sample Collection, Storage, and Characterization2. DNA Extraction Methods3. DNA Quantitation 4. PCR Amplification: Capabilities and Cautions5. Short Tandem Repeat (STR) Loci and Kits6. Capillary Electrophoresis: Principles and Instrumentation7. Quality Assurance and Validation8. DNA Databases: Uses and Issues9. Missing Persons and Disaster Victim Identification Efforts10. Degraded DNA11. Low-Level DNA Testing: Issues, Concerns, and Solutions12. Single Nucleotide Polymorphisms and Applications13. Y-Chromosome DNA Testing14. Mitochondrial DNA Analysis15. X-Chromosome Analysis16. Non-Human DNA17. New Technologies and Automation18. Legal Aspects of DNA Testing and the Scientific Expert in CourtAppendix 1 Reported Sizes and Sequences of STR AllelesAppendix 2 Familial DNA Searches: Potential, Pitfalls, and Privacy ConcernsAppendix 3 List of Suppliers for DNA Instruments, Reagents, ServicesAppendix 4 Interviews Supporting Legal Aspects of DNA Testing

Subject Areas: Forensic medicine [MMQ], Forensic science [JKVF1], Crime & criminology [JKV]