Addition, Elimination and Substitution: Markovnikov, Hofmann, Zaitsev and Walden
Discovery and Development

Traces the history of the most important empirical rules in organic chemistry and discusses their effects on developing new reactions

David E. Lewis (Author)

9780128210277

Paperback, published 7 July 2022

280 pages, Approx. 250 illustrations
22.9 x 15.2 x 1.9 cm, 0.45 kg

Approx.272 pages

1. Introduction: The Place of Antagonism and Feuds in Advancing Science
2. Vladimir Vasil'evich Markovnikov and Markovnikov's Rule for Addition
3. Aleksandr Mikhailovich Zaitsev and Zaitsev's Rule for Elimination
4. Markovnikov's Rule and Controversies Over It
5. Mechanistic Considerations in Bimolecular Elimination Reactions
6. Development of Highly Regioselective Addition Reactions
7. Development of Highly Regiospecific Alkene Syntheses

Subject Areas: Biochemistry [PSB], Organic chemistry [PNN], Pharmacology [MMG]