A History of Nerve Functions
From Animal Spirits to Molecular Mechanisms

Complete history of nerve cell function from the ancient Greeks to our present knowledge.

Sidney Ochs (Author)

9780521247429, Cambridge University Press

Hardback, published 19 April 2004

450 pages, 124 b/w illus.
23.6 x 16 x 2.5 cm, 0.715 kg

'It would be difficult to identify any book in recent years that could provide as much excitement and profound insight into this field in the context of its broad history… it would be difficult to match the informed succinct style of this remarkable pioneer who has bought us his wonderfully readable reflections on the origins of those questions that continue to attract and to inspire increasing numbers of talented individuals to the benches of neuroscience research.' Journal of the History of the Neuroscienes

Recent developments have extended our knowledge of the basic functions of nerves: notably, the demonstration of the mechanism within nerve fibers which transports a wide range of essential materials. In order to understand how this discovery occurred, it is necessary to examine its history. The story begins in ancient Greece when nerves were conceived of as channels through which animal spirits carried sensory impressions to the brain. As science developed, the discoveries of various physical and chemical agents supplanted the agency of animal spirits until the molecular machinery of transport was recognized. In this fascinating and complete history, Sidney Ochs begins with a chronological look at this path of discovery, followed in the second half by a thematic approach wherein the author describes the electrical nature of the nerve impulse, fiber form and its changes in degeneration and regeneration, reflexes, learning, memory and other higher functions in which transport participates.

1. Introduction: Greek science and the recognition of nerves' function
2. Galen's physiology of the nervous system
3. Nerve, brain, and soul in the Middle Ages
4. Renaissance and the New Physiology
5. New physical and chemical models of nerve in the Enlightenment
6. New systematizations of nerve function in the Enlightenment
7. Electricity as the Agent of Nerve Action
8. Nerve fiber form and transformation
9. Wallerian degeneration: early and late phases
10. Nerve regeneration
11. Characterization of axoplasmic transport
12. Molecular models of transport
13. Actions of neurotoxins and neuropathic changes related to transport
14. Purposeful reflexes and instinctive behavior
15. Neural events related to learning and memory
16. Epilogue
Bibliography.

Subject Areas: Neurosciences [PSAN]