{"product_id":"vanilloid-receptor-trpv1-in-drug-discovery-targeting-pain-and-other-pathological-disorders-hardback-9780470175576","title":"Vanilloid Receptor TRPV1 in Drug Discovery; Targeting Pain and Other Pathological Disorders (Hardback) 9780470175576","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eVanilloid Receptor TRPV1 in Drug Discovery\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eTargeting Pain and Other Pathological Disorders\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eArthur Gomtsyan (Edited by), A Gomtsyan (Author), Connie R. Faltynek (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470175576, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 12 March 2010\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e488 pages\u003cbr\u003e24.1 x 16 x 2.6 cm, 0.789 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cb\u003eExamines the emerging therapeutic role of TRPV1\u003c\/b\u003e  \u003cp\u003eTRPV1 is considered an integrator of noxious stimuli and therefore may be at a crossroads for pain transmission pathways. Because of its potential for managing multiple pain types, including osteoarthritis, chronic low back pain, neuropathic pain, and cancer pain, some consider it \"the holy grail\" of pain management. This dedicated reference summarizes available data related to the potential therapeutic utility for TRPV1 ligands.\u003c\/p\u003e \u003cp\u003eWith contributions from many of the world's leading experts on TRP channels, \u003ci\u003eVanilloid Receptor TRPV1 in Drug Discovery\u003c\/i\u003e covers the important TRPV1 target for drugs to treat painful conditions such as inflammation, arthritis, and cancer pain. The book discusses:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e \u003cp\u003eRecent advances in biology, chemistry, and pharmacology at both the preclinical and clinical stage of the dynamic area of TRPV1 drug discovery research\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eThe potential for drugs targeting TRPV1 in painful conditions such as inflammation, arthritis, and cancer\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eThe development of analgesic drugs\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eOther applications for TRPV1, including the treatment of respiratory disease and diabetes\u003c\/p\u003e \u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eFeaturing data relevant to the therapeutic potential of TRPV1 and the medicinal chemistry involved in designing TRPV1 antagonists, \u003ci\u003eVanilloid Receptor TRPV1 in Drug Discovery\u003c\/i\u003e is a key tool for researchers in the pharmaceutical industry and academia involved in pain, ion channels, and analgesic drug development.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePreface and Acknowledgments.  \u003cp\u003eForeword.\u003c\/p\u003e \u003cp\u003eContributors.\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART I INTRODUCTION TO THE TRP CHANNELS.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 TRP Channels and Human Diseases (\u003ci\u003eBernd Nilius and Rudi Vennekens\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e2 Role of TRP Channels in Pain: An Overview (\u003ci\u003eArpad Szallasi\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e3 Biochemical Pharmacology of TRPV1: Molecular Integrator of Pain Signals (\u003ci\u003eCarol S. Surowy, Philip R. Kym, and Regina M. Reilly\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e4 TRPV1 Genetics (\u003ci\u003eRuslan Dorfman, Hubert Tsui, Michael W. Salter, and H.-Michael Dosch\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART II ROLE FOR TRPV1 IN PAIN STATES.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5 TRPV1 and Inflammatory Pain (\u003ci\u003eAnindya Bhattacharya, Sonya G. Lehto, and Narender R. Gavva\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e6 Role of TRPV1 Receptors in Osteoarthritic Pain (\u003ci\u003eShailen K. Joshi and Prisca Honore\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e7 TRPV1 and Bone Cancer Pain (\u003ci\u003eJuan Miguel Jimenez-Andrade and Patrick Mantyh\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e8 TRPV1 in Visceral Pain and Other Visceral Disorders (\u003ci\u003eAntónio Avelino and Francisco Cruz\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e9 TRPV1 Receptors and Migraine (\u003ci\u003ePhilip R. Holland and Peter J. Goadsby\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e10 TRPV1 in Neuropathic Pain and Neurological and Neuropsychiatric Disorders (\u003ci\u003eEnza Palazzo, Katarzyna Starowicz, Sabatino Maione, and Vincenzo Di Marzo\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART III TRPV1 ANTAGONISTS AND AGONISTS AS NOVEL ANALGESIC DRUGS.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e11 Aryl-Urea Class and Related TRPV1 Antagonists (\u003ci\u003eArthur Gomtsyan\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e12 2-Pyridinylpiperazine Carboxamide Class and Related TRPV1 Antagonists (\u003ci\u003eNatalie A. Hawryluk and Nicholas I. Carruthers\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e13 TRPV1 Agonist Approaches for Pain Management (\u003ci\u003eKeith R. Bley\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART IV ROLE FOR TRPV1 IN OTHER PHYSIOLOGICAL PROCESSES BESIDES PAIN TRANSMISSION.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e14 The TRPV1 Channel in Normal Thermoregulation: What Have We Learned from Experiments Using Different Tools? (\u003ci\u003eAndras Garami, Maria C. Almeida, Tatiane B. Nucci, Tamara Hew-Butler, Renato N. Soriano, Eszter Pakai, Kazuhiro Nakamura, Shaun F. Morrison, and Andrej A. Romanovsky\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e15 The Role of TRPV1 in Respiratory Diseases (\u003ci\u003eSerena Materazzi, Alain Tchoimou, Romina Nassini, Marcello Trevisani, and Pierangelo Geppetti\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e16 The Role of TRPV1 in Diabetes (\u003ci\u003eHubert Tsui, Ruslan Dorfman, Michael W. Salter, and H.-Michael Dosch\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eAfterword.\u003c\/p\u003e \u003cp\u003eIndex.\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52257149419800,"sku":"9780470175576","price":99.49,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780470175576.jpg?v=1781277653","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/vanilloid-receptor-trpv1-in-drug-discovery-targeting-pain-and-other-pathological-disorders-hardback-9780470175576","provider":"Freshly Printed Books","version":"1.0","type":"link"}