{"product_id":"validamycin-and-its-derivatives-discovery-chemical-synthesis-and-biological-activity-paperback-9780081009994","title":"Validamycin and Its Derivatives; Discovery, Chemical Synthesis, and Biological Activity (Paperback \/ softback) 9780081009994","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eValidamycin and Its Derivatives\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eDiscovery, Chemical Synthesis, and Biological Activity\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cem\u003e\u003cp\u003eReviews how medicinal chemists are employing the bioactive properties of validamycin and its related agricultural antibiotics in novel pharmaceutical drugs\u003c\/p\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eXiaolong Chen (Author), Yuele Lu (Author), Yongxian Fan (Author), Yinchu Shen (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780081009994, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePaperback \/ softback, published 4 April 2017\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e340 pages\u003cbr\u003e22.9 x 15.1 x 2.2 cm, 0.56 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003eValidamycin and Its Derivatives: Discovery, Chemical Synthesis and Biological Activity\u003c\/i\u003e presents, for the first time, a complete review of the underlying chemistry, synthesis, behavior and application of these compounds.\u003c\/p\u003e  \u003cp\u003eBeginning with an introduction to validamycin, the book then outlines the key elements of its discovery and production, including details of its structures, isolation, analysis, and issues relating to its large scale production. \u003c\/p\u003e  \u003cp\u003eBiological activities are then explored in more detail, followed by details of biosynthesis. Further to this, the chemical synthesis of validamycin and its intermediates, including valienamine, validamine, valiolamine, and validoxylamines is reviewed, before preparation of these derivatives and their biological activities are explored. \u003c\/p\u003e  \u003cp\u003eFinally, the book concludes with a discussion of the economic aspects of working with validamycin and its potential in future applications and trends. With its detailed chemical coverage from a team of expert authors, this detailed guide can be applied to the large-scale industrial production of antibiotics and the adaptation of bioactive agents, from agricultural, to novel pharmaceutical applications.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e1. An Introduction to Validamycins and Their Derivatives 2. Production of Validamycins 3. Bioactivities of Validamycins and Related Natural Compounds 4. Chemical Synthesis of Validamycin and Related Natural Compounds 5. Voglibose: An Important Drug for Type 2 Diabetes 6. \u003ci\u003eN\u003c\/i\u003e-Octyl-ß-Valienamine and \u003ci\u003eN\u003c\/i\u003e-Octyl-4-\u003ci\u003eepi\u003c\/i\u003e-ß-Valienamine: Two Highly Potent Drug Candidates for Chemical Chaperone Therapy 7. Prospects and Concluding Remarks\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Organic chemistry [\u003ca title=\"See our other books on Organic chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Organic%20chemistry%20%5BPNN%5D%22\"\u003ePNN\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Elsevier","offers":[{"title":"Default Title","offer_id":46649150341400,"sku":"9780081009994","price":145.39,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780081009994_58b89cec-9d1a-40a6-8857-c9ce2f3ad1cd.jpg?v=1695004157","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/validamycin-and-its-derivatives-discovery-chemical-synthesis-and-biological-activity-paperback-9780081009994","provider":"Freshly Printed Books","version":"1.0","type":"link"}