{"product_id":"trp-channels-as-therapeutic-targets-from-basic-science-to-clinical-use-hardback-9780124200241","title":"TRP Channels as Therapeutic Targets; From Basic Science to Clinical Use (Hardback) 9780124200241","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eTRP Channels as Therapeutic Targets\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eFrom Basic Science to Clinical Use\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cem\u003eThis comprehensive resource fills an important gap by focusing on recent clinical data and therapeutic targeting of TRP channels\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eArpad Szallasi (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780124200241\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 14 March 2015\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e536 pages, 40 illustrations\u003cbr\u003e23.4 x 19 x 3.1 cm, 1.27 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\"...provides a useful meta-review of a field in which numerous journal reviews have been published, few of which approach the big picture and detailed historical assessment of drug development and testing found here. Score: 84 - 3 Stars\" --\u003cb\u003eDoody's\u003c\/b\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003eTRP Channels as Therapeutic Targets: From Basic Science to Clinical Use\u003c\/i\u003e is authored by experts across academia and industry, providing readers with a complete picture of the therapeutic potential and challenges associated with using TRP channels as drug targets. \u003c\/p\u003e  \u003cp\u003eThis book offers a unique clinical approach by covering compounds that target TRP channels in pre-clinical and clinical phases, also offering a discussion of TRP channels as biomarkers. \u003c\/p\u003e  \u003cp\u003eAn entire section is devoted to the novel and innovative uses of these channels across a variety of diseases, offering strategies that can be used to overcome the adverse effects of first generation TRPV1 antagonists. \u003c\/p\u003e  \u003cp\u003eIntended for all researchers and clinicians working toward the development of successful drugs targeting TRP channels, this book is an essential resource chocked full of the latest clinical data and findings.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e1. Introduction\u003cbr\u003e2. Hereditary TRP Channelopathies\u003cbr\u003e3. Changes in TRP Channel Expression in Acquired Diseases\u003cbr\u003e4. TRP Gene Polymorphism and Disease Risk\u003cbr\u003e5. Topical Capsaicin for Pain Relief\u003cbr\u003e6. TRPV1 agonist cytotoxicity for chronic pain relief\u003cbr\u003e7. Intravesical Capsaicin and Resiniferatoxin for Bladder Disorders\u003cbr\u003e8. Clinical and Preclinical Experience with TRPV1 Antagonists as Potential Analgesic Agents \u003cbr\u003e9. TRPA1 Antagonists for Pain Relief\u003cbr\u003e10. TRPA Antagonistsas Therapeutic Strategies to Reduce the Symptoms and Pathophysiology of Respiratory Disorders\u003cbr\u003e11. TRPV3 Receptors as Drug Targets: A Decade of Learning\u003cbr\u003e12. Small Molecule Agonists and Antagonists of TRPV4\u003cbr\u003e13. Potential Therapeutic Applications for TRPV4 Antagonists in Lung Disease\u003cbr\u003e14. TRPM8 as a Target for Analgesia\u003cbr\u003e15. TRP Channels: Connectivity to Cerebral Vascular Disease\u003cbr\u003e16. TRP Channels' Key Role in the Transduction of Itch\u003cbr\u003e17. Role of TRP Channels in Skin Diseases\u003cbr\u003e18. TRP Channels in Obesity\/Metabolic Syndrome\u003cbr\u003e19. TRP Channels in Diabetes\u003cbr\u003e20. TRP Channels and Ca²+ Entry in Cardiac Disease\u003cbr\u003e21. The Contribution of TRP Channels to Pathophysiological Regulation of the Gastrointestinal Tract\u003cbr\u003e22. Cancer: Oncogenic and Anti-Oncogenic TRP Channels as Biomarkers and Therapeutic Targets\u003cbr\u003e23. TRP Channels in the Brain\u003cbr\u003e24. A: Mucolipidosis and TRPML Channels\u003cbr\u003e24 B: TRPML1-dependent Processes as the Therapeutic Targets\u003cbr\u003e25. TRPs in respiratory disorders: opportunities beyond TRPA1\u003cbr\u003e26. Concluding Remarks\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Biochemistry [\u003ca title=\"See our other books on Biochemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biochemistry%20%5BPSB%5D%22\"\u003ePSB\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e], Physiology [\u003ca title=\"See our other books on Physiology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Physiology%20%5BMFG%5D%22\"\u003eMFG\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Freshly Printed Books","offers":[{"title":"Default Title","offer_id":46649417498904,"sku":"9780124200241","price":117.57,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780124200241.jpg?v=1694100858","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/trp-channels-as-therapeutic-targets-from-basic-science-to-clinical-use-hardback-9780124200241","provider":"Freshly Printed Books","version":"1.0","type":"link"}